{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:04:34Z","timestamp":1791209074274,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Structural alterations  of small arteries in patients with essential hypertension are  characterized by inward eutrophic remodeling. However, small arteries  in patients with secondary hypertension, as well as in experimental  models of hypertension with high circulating renin, are characterized  by inward hypertrophic remodeling, which is characterized by smooth  muscle cell hypertrophy in animal models. The aim of our  study was to determine whether remodeling of subcutaneous small  arteries in patients with secondary forms of hypertension is associated  with smooth muscle cell hypertrophy and\/or alterations in  the elastic modulus of the vessel wall. Fifteen patients with  renovascular hypertension, 9 with primary aldosteronism, and 13 with  essential hypertension and 9 normotensive subjects were included in the  study. A biopsy of subcutaneous fat was taken from all subjects. Small  arteries were dissected, and morphology was determined on a  micromyograph. Unbiased estimates of cell volume and number were made  in fixed material. From the resting tension\u2013internal circumference  relation of the small arteries, the incremental elastic modulus was  calculated and plotted as a function of wall stress. Blood pressure was  greater in patients with essential hypertension, renovascular  hypertension, or primary aldosteronism than in normotensive subjects,  but no significant difference was observed among the 3 groups of  hypertensive patients. The media\/lumen ratio, the medial  cross-sectional area, and the smooth muscle cell volume were  significantly greater in patients with renovascular hypertension than  in normotensive subjects and patients with essential hypertension. No  difference in cell number or in the elastic properties was observed  among the 4 groups of subjects. In conclusion, our data demonstrate for  the first time that a pronounced activation of the  renin-angiotensin-aldosterone system is  associated with vascular smooth muscle cell hypertrophy in  human hypertension in a manner similar to that found in animal  models.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.4.931","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"931-935","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":90,"title":["Cellular Hypertrophy in Subcutaneous Small Arteries of Patients With Renovascular Hypertension"],"prefix":"10.1161","volume":"35","author":[{"given":"Damiano","family":"Rizzoni","sequence":"first","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Porteri","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Guefi","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Piccoli","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizo","family":"Castellano","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Pasini","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lorenza","family":"Muiesan","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael John","family":"Mulvany","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Agabiti","family":"Rosei","sequence":"additional","affiliation":[{"name":"From the Chair of Internal Medicine, Department of Medical and Surgical  Sciences, University of Brescia, Brescia, Italy, and the Department of  Pharmacology (M.J.M.), University of Aarhus, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"347","volume":"63","year":"1982","unstructured":"Folkow B. 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