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Renal function and hemodynamics, body fluid  volumes, and relevant hormones and genotypes were measured.  Subjects with high personal and parental blood pressures had the  highest levels of glomerular filtration rate  (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02) and plasma active renin concentration and low  levels of exchangeable sodium and plasma volume  (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02). High glomerular filtration rate  was not associated with differences in urinary kallikrein or  prostaglandins. Polymorphisms of the renin,  angiotensin-converting enzyme, and  angiotensinogen genes were not associated with differences  in glomerular filtration rate or renin. Subjects with high  personal, but low parental, blood pressures had low exchangeable sodium  and plasma volumes (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.02) but normal  glomerular filtration rates. In this population,  extracellular volume depletion and high renin are correlates of high  blood pressure in early adulthood, and glomerular  hyperfiltration is a feature of those who also have familial  predisposition to high blood pressure.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.35.4.952","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"952-957","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Glomerular Hyperfiltration, High Renin, and Low- Extracellular Volume in High Blood Pressure"],"prefix":"10.1161","volume":"35","author":[{"given":"Stephen B.","family":"Harrap","sequence":"first","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan D.","family":"Cumming","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Davies","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J. W.","family":"Foy","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fraser","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Kamitani","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Michael","family":"Connor","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F.","family":"Lever","sequence":"additional","affiliation":[{"name":"From the Department of Physiology (S.B.H., A.K.), The University of  Melbourne, Parkville, Victoria, Australia; the MRC Blood Pressure Unit (R.F.,  A.F.L.) and the Department of Medicine &amp; Therapeutics (D.L.D.), Western  Infirmary, Glasgow, UK; the Department of Medicine (A.D.C.), Royal Infirmary,  Edinburgh, UK; the Northern Regional Health Authority (C.J.W.F.), Newcastle  upon Tyne, UK; Duncan Guthrie Institute of Medical Genetics (J.M.C.),  Yorkhill, Glasgow, UK; and the Department of Public..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham C. 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