{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:05:13Z","timestamp":1788289513376,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,8]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Although  echocardiography is a useful diagnostic  tool in hypertrophic cardiomyopathy (HCM), it is  sometimes difficult to differentiate it from hypertensive heart disease  (HHD): some patients with HCM show symmetrical hypertrophy,  whereas patients with HHD sometimes show asymmetrical septal  hypertrophy. We used a radioiodinated  long-chain fatty acid tracer to visualize the altered myocardial fatty  acid metabolism of HCM and HHD. Carnitine is the essential  substance for the \u03b2-oxidation of long-chain fatty acids. We recently  reported that serum free carnitine levels in HCM were elevated and that  they were significantly correlated with the severity of myocardial  fatty acid metabolic disorder. Therefore, we investigated  serum carnitine levels in patients with HCM and HHD, which can  contribute to the differentiation of each other. We studied 56 patients  with HCM and 20 patients with essential hypertension. Serum free  carnitine levels were significantly higher in patients with HCM than  those with HHD (HCM 52.5\u00b19.5 nmol\/mL, HHD 46.6\u00b16.4 nmol\/mL,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01), but they showed no statistical difference  between patients with HHD and normal subjects. Serum acylcarnitine  levels were significantly lower in patients with HCM than those with  HHD (HCM 10.1\u00b14.0 nmol\/mL, HHD 14.5\u00b14.9 nmol\/mL,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0005), although they did not differ between  patients with HHD and normal subjects. Scintigraphic analyses  with a long-chain fatty acid analog revealed that myocardial tracer  uptake was much reduced in patients with HCM compared with that in  patients with HHD (quantitative analysis: HCM 2.11\u00b10.12, HHD  2.22\u00b10.17,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05; semiquantitative analysis:  HCM 13.6\u00b16.3, HHD 2.0\u00b11.5,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001). In conclusion,  the differences in serum carnitine levels between HCM and HHD reflect  altered myocardial fatty acid metabolic impairment, and the  levels can help to distinguish these 2 diseases.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.36.2.215","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"215-219","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Can Serum Carnitine Levels Distinguish Hypertrophic Cardiomyopathy From Hypertensive Hearts?"],"prefix":"10.1161","volume":"36","author":[{"given":"Tomoki","family":"Nakamura","sequence":"first","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sugihara","sequence":"additional","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Azuma","sequence":"additional","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"From the Second Departments of Medicine (T.N., N.K., S.Y., A.A., M.N.)  and Radiology (H.S.), Kyoto Prefectural University of Medicine, Kyoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.47.2.225"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(83)80269-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.16.377"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80028-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80190-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.44.4.395"},{"key":"e_1_3_2_7_2","unstructured":"Narita M Kurihara T Usami M Honda M. 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