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In the present study, the  formation of cholesterol oxidation products was used as  a measure of in vivo lipid peroxidation after hypertension induced by  coarctation of the aorta in New Zealand White rabbits. The rabbits were  fed a standard chow diet devoid of cholesterol or  cholesterol oxidation products such that the measured  cholesterol oxides in the plasma and aortic tissues would  most plausibly arise from endogenous oxidation of  cholesterol. After 12 weeks of hypertension, all of the  measured cholesterol oxides increased significantly over  baseline levels in the surgically coarctated animals; however, this  increase was significantly less in hypertensive probucol-treated  animals. Similarly, the cholesterol oxide content of aortic  tissue from the surgically coarctated animals was significantly greater  than that found in normotensive control aortas, and probucol treatment  significantly reduced the increase in cholesterol oxide  content of aortic tissue relative to that of hypertensive animals not  receiving the antioxidant. These findings in hypertensive animals  suggest that cholesterol oxidation products measured in  plasma and aortic tissue can be derived from endogenous  free radical activity and that this activity is enhanced under specific  pathological conditions.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.36.3.436","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"436-441","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Probucol Reduces Oxysterol Formation in Hypertensive Rabbits"],"prefix":"10.1161","volume":"36","author":[{"given":"Howard N.","family":"Hodis","sequence":"first","affiliation":[{"name":"From the University of Southern California School of Medicine,  Atherosclerosis Research Unit, Division of Cardiology (H.N.H., S.M., W.J.M.,  A.S.), and Department of Preventive Medicine (H.N.H., W.J.M.), Los Angeles;  and the University of Southern California School of Pharmacy, Department of  Molecular Pharmacology and Toxicology (H.N.H., A.S.), Los Angeles."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"From the University of Southern California School of Medicine,  Atherosclerosis Research Unit, Division of Cardiology (H.N.H., S.M., W.J.M.,  A.S.), and Department of Preventive Medicine (H.N.H., W.J.M.), Los Angeles;  and the University of Southern California School of Pharmacy, Department of  Molecular Pharmacology and Toxicology (H.N.H., A.S.), Los Angeles."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy J.","family":"Mack","sequence":"additional","affiliation":[{"name":"From the University of Southern California School of Medicine,  Atherosclerosis Research Unit, Division of Cardiology (H.N.H., S.M., W.J.M.,  A.S.), and Department of Preventive Medicine (H.N.H., W.J.M.), Los Angeles;  and the University of Southern California School of Pharmacy, Department of  Molecular Pharmacology and Toxicology (H.N.H., A.S.), Los Angeles."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Sevanian","sequence":"additional","affiliation":[{"name":"From the University of Southern California School of Medicine,  Atherosclerosis Research Unit, Division of Cardiology (H.N.H., S.M., W.J.M.,  A.S.), and Department of Preventive Medicine (H.N.H., W.J.M.), Los Angeles;  and the University of Southern California School of Pharmacy, Department of  Molecular Pharmacology and Toxicology (H.N.H., A.S.), Los Angeles."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450030078036"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(77)90027-2"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(83)90005-1"},{"key":"e_1_3_2_4_2","first-page":"474","volume":"24","year":"1986","unstructured":"Uysal M, Bulur H, Sener D, Oz H. 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