{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:56:58Z","timestamp":1787597818779,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Experimental  narrowing of the main renal artery to produce hypertension increases  the aorta-glomerular capillary pressure difference and  vascular resistance. This article examines the hypothesis that  hypertension also may be caused by structural changes that narrow  intrarenal blood vessels, similarly increasing  preglomerular vascular resistance and the  aortic-glomerular capillary pressure gradient. There is  evidence of both wall hypertrophy and lumen narrowing of  the preglomerular arteries in spontaneously hypertensive  rats, with increased preglomerular resistance and  aortic-glomerular capillary pressure difference. We have  also attempted to induce structural changes in  renal-preglomerular vessels experimentally by infusing  angiotensin II at low doses (0.5 to 4.5 ng\/kg per minute)  into the renal artery of Sprague-Dawley rats and greyhound dogs for up  to 4 weeks. This angiotensin II infusion produced apparent  dose-related effects on preglomerular vessel structure and  hypertension. The possibility that hypertension may be induced by  structural changes in preglomerular resistance vessel  walls, by simulation of the hemodynamic effects of main  renal artery stenosis, deserves further investigation.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.36.4.648","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"648-652","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Renovascular Hypertension"],"prefix":"10.1161","volume":"36","author":[{"given":"W. P.","family":"Anderson","sequence":"first","affiliation":[{"name":"From the Department of Physiology, Monash University, Melbourne,  Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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