{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:10:32Z","timestamp":1773292232177,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Both  angiotensin II and vascular endothelial  growth factor are angiogenic agents that have recently been implicated  in the pathogenesis of proliferative diabetic  retinopathy. In this study, retinal neovascularization  was examined in a model of retinopathy of prematurity  with the use of neonatal transgenic (mRen-2)27 rats, which overexpress  renin in tissues, and Sprague-Dawley rats. Blockers of the  renin-angiotensin system were administered during the  neovascularization period. The ACE inhibitor  lisinopril and the angiotensin type 1 receptor  antagonist losartan both increased retinal renin  levels and prevented inner retinal blood vessel growth. Quantitative in  situ hybridization revealed that the expression of vascular  endothelial growth factor and its type 2 receptor in  the inner retina and proliferating blood vessels were increased in rats  with retinopathy of prematurity. Lisinopril  reduced both retinal vascular endothelial growth factor  and its type 2 receptor mRNA in retinopathy of  prematurity rats, whereas losartan had no effect. It is  predicted that agents that interrupt the renin-angiotensin  system may play an important role as retinoprotective agents in various  forms of proliferative  retinopathy.<\/jats:p>","DOI":"10.1161\/01.hyp.36.6.1099","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"1099-1104","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":159,"title":["Retinal Neovascularization Is Prevented by Blockade of the Renin-Angiotensin System"],"prefix":"10.1161","volume":"36","author":[{"given":"Christina J.","family":"Moravski","sequence":"first","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Bertram","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnaz","family":"Shahinfar","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandford L.","family":"Skinner","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); the Department of  Medicine, The University of Melbourne, St Vincents Hospital, Fitzroy,  Victoria, Australia (D.J.K., R.E.G.); the Department of Medicine, The  University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg  West, Victoria, Australia (M.E.C.); the Department of Anatomy, Monash  University, Clayton, Victoria, Australia (J.F.B.); and Merck Research ..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Wilkinson-Berka","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, The University of Melbourne,  Parkville, Victoria, Australia (C.J.M., S.L.S., J.L.W.-B.); 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