{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:40:22Z","timestamp":1715535622872},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014We have used comparative  sequence analysis to evaluate a putative silencer element that  has been proposed to be involved in the differential tissue-expression  of the murine renin genes:\n            <jats:italic>Ren-1<\/jats:italic>\n            and\n            <jats:italic>Ren-2<\/jats:italic>\n            . In the mouse, these genes share a similar pattern  of tissue-specific renin expression. One significant difference is seen  in the submandibular gland (SMG) where renin expression from the\n            <jats:italic>Ren-2<\/jats:italic>\n            locus is 100-fold greater than the expression from  the\n            <jats:italic>Ren-1<\/jats:italic>\n            locus. One model proposes that this  differential expression arises from the interplay among a negative  regulatory element and a cAMP responsive element, their respective  binding factors, and the disruption of the negative regulatory element  by an insertion (M2) that is found in\n            <jats:italic>Ren-2<\/jats:italic>\n            but not in\n            <jats:italic>Ren-1<\/jats:italic>\n            . The abrogation of the negative regulatory  element\u2019s function as a result of the M2 insertion was proposed to be  specifically responsible for the higher level of\n            <jats:italic>Ren-2<\/jats:italic>\n            expression in the SMG as compared with\n            <jats:italic>Ren-1<\/jats:italic>\n            . We have  assessed this hypothesis by looking at an allelic variant in the  closely related mouse species\n            <jats:italic>M. hortulanus<\/jats:italic>\n            . This  species shares the same high level of\n            <jats:italic>Ren-2<\/jats:italic>\n            expression  in the SMG as seen in other\n            <jats:italic>Ren-2<\/jats:italic>\n            positive mouse  strains. However, the\n            <jats:italic>Ren-2 M. hortulanus<\/jats:italic>\n            allele  does not appear to contain the disruptive M2 element according to  restriction-enzyme mapping. Our sequence analysis confirms that  the\n            <jats:italic>M. hortulanus Ren-2<\/jats:italic>\n            allele contains the same  sequence elements present in the DBA\/2\n            <jats:italic>Ren-2<\/jats:italic>\n            allele except for the M2 element. Moreover, the proposed negative  regulatory element is intact at the sequence level in\n            <jats:italic>Ren-2<\/jats:italic>\n            <jats:italic>M. hortulanus<\/jats:italic>\n            allele.  This analysis suggests that any involvement of the negative  regulatory element in differential\n            <jats:italic>Ren-1<\/jats:italic>\n            and\n            <jats:italic>Ren-2<\/jats:italic>\n            expression in the SMG is not as straightforward as  previously hypothesized.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.1.105","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"105-109","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating a Model of an NRE Mediated Tissue-Specific Expression of Murine Renin Genes"],"prefix":"10.1161","volume":"37","author":[{"given":"J. Pablo","family":"Abonia","sequence":"first","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Howles","sequence":"additional","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth J.","family":"Abel","sequence":"additional","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Black","sequence":"additional","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig A.","family":"Jones","sequence":"additional","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W.","family":"Gross","sequence":"additional","affiliation":[{"name":"From the Department of Molecular and Cellular Biology, Roswell Park  Cancer Institute (J.P.A., T.A.B., C.A.J., K.W.G.), Buffalo, NY; School of  Medicine and Biomedical Sciences(J.P.A., T.A.B.), Buffalo NY; the Department  of Pathology and Laboratory Medicine, University of Cincinnati College of  Medicine (P.N.H.), Cincinnati, Ohio; and Sequenom Inc (K.J.A.), San Diego,  Calif."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.5.2111"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/124.4.937"},{"key":"e_1_3_2_3_2","first-page":"32","volume":"2","year":"1992","unstructured":"Abel KJ, Howles PN, Gross, KW. DNA insertions distinguish the duplicated renin genes of DBA\/2 and M. hortulanus mice. Mamm Genome. 1992;2:32\u201340.","journal-title":"Mamm Genome"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.18.6196"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","unstructured":"Jones CA Fabian JR Abel KJ Sigmund CD Gross KW. The regulation of renal and extrarenal renin gene expression in the mouse. In: Raizada MK Phillips MI Sumners C eds. Cellular and Molecular Biology of the Renin-Angiotensin System. 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