{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:08:24Z","timestamp":1758632904656},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Neurovascular contact of  the left rostral ventrolateral medulla has been implicated in the  pathogenesis of \u201cessential\u201d hypertension, and recent intervention  studies suggest that surgical decompression of the ventrolateral  medulla lowers blood pressure in these patients. We assessed the  prevalence of this vascular anomaly in patients with essential  hypertension by using an advanced MRI technique. We performed MRI of  the brain stem in 125 hypertensive patients and in 105 age-matched,  sex-matched, and body mass index\u2013matched normotensive control  subjects. Imaging of the root-entry zone of cranial nerves IX and X was  performed by combining a high-resolution 3D constructive interference  in steady-state sequence with a flow-sensitive time-of-flight  technique, and images were independently assessed by 4 readers using  predefined criteria. Left-sided neurovascular contact was found in 23%  of the hypertensive patients and in 16% of the normotensive  individuals (\n            <jats:italic>P<\/jats:italic>\n            =0.12). Blood pressure level, heart rate,  and number of antihypertensive medications in treated hypertensive  patients were similar among patients with positive, borderline, and  negative brain stem findings. Our findings cast doubt on the importance  of left-sided neurovascular contact as a frequent cause of essential  hypertension or as a major factor determining the severity of  hypertension in patients with this anomaly.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.1.176","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"176-181","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Neurovascular Contact of Cranial Nerve IX and X Root-Entry Zone in Hypertensive Patients"],"prefix":"10.1161","volume":"37","author":[{"given":"Henriette","family":"Hohenbleicher","sequence":"first","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan A.","family":"Schmitz","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Christian","family":"Koennecke","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Offermann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Offermann","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Zeytountchian","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Ju\u0308rgen","family":"Wolf","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Distler","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya M.","family":"Sharma","sequence":"additional","affiliation":[{"name":"From the Department of Internal Medicine (H.H., R.O., J.O., H.Z., A.D.,  A.M.S.), Division of Endocrinology and Nephrology, the Department of Radiology  (S.A.S., K.-J.W.), and the Department of Neurology (H.-C.K.),  Universita\u0308tsklinikum Benjamin Franklin, Berlin, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","unstructured":"Oparil S Chen YF Berecek KH Calhoun DA Wyss JM. 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