{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:54:03Z","timestamp":1762271643685},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>Calcitonin  receptor\u2013like receptor\/receptor activity\u2013modifying protein 2  (CRLR\/RAMP2) and CRLR\/RAMP3 complexes have been reported to be specific  adrenomedullin (AM) receptors. In the present study, we evaluated  the pathophysiological significance of renal AM and  its receptor system in aortocaval shunt (ACS) rats. Renal AM levels  were measured serially during 5 weeks after the operation. Renal gene  expressions of AM, CRLR, RAMP2, and RAMP3 were measured at 2 weeks  (decompensated phase) and 5 weeks (compensated phase) after the  operation. Immunohistochemical localizations of renal AM were also  evaluated. Furthermore, the relations between urinary sodium excretion  (UNaV) and renal AM levels were evaluated. Renal AM levels were higher  in ACS than in control animals only at 1, 2, and 3 weeks after the  operation. At 2 weeks after the operation, renal AM mRNA expression was  also higher in ACS than in control animals. CRLR, RAMP2, and RAMP3  mRNAs were expressed in the kidney, but there were no differences  between the 2 groups. Immunohistochemistry revealed the positive AM  immunostaining within the renal tubular cells, and it  was more intense in ACS than in control animals. There were significant  correlations between UNaV and renal AM levels. At 5 weeks after the  operation, there were no differences in mRNA levels of AM, CRLR, RAMP2,  and RAMP3 between the 2 groups. There was a significant correlation  between UNaV and medullary AM levels. The present findings suggest  that increased renal AM levels in decompensated heart failure,  presumably due to increased AM production in renal tubules, in  part, are involved in the regulation of sodium excretion.<\/jats:p>","DOI":"10.1161\/01.hyp.37.2.216","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"216-222","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Alterations of Intrarenal Adrenomedullin and Its Receptor System in Heart Failure Rats"],"prefix":"10.1161","volume":"37","author":[{"given":"Fumiki","family":"Yoshihara","sequence":"first","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Nishikimi","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Okano","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Horio","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikao","family":"Yutani","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Takishita","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Ohe","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kangawa","sequence":"additional","affiliation":[{"name":"From the Research Institute (F.Y., I.O., H.M., K.K.), Division of  Hypertension (T.H., S.T.), Division of Pathology (C.Y.), National  Cardiovascular Center, Osaka, Japan; Department of Cardiovascular Medicine  (T.N.), Dokkyo Medical School, Tochigi, Japan; and Department of  Cardiovascular Medicine (T.O.), Okayama University Medical School, Okayama,  Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"F657","volume":"268","year":"1995","unstructured":"Jougasaki M, Wei CM, Aarhus LL, Heublein DM, Sandberg SM, Burnett JC Jr. Renal localization and actions of adrenomedullin: a natriuretic peptide. 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