{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:59:58Z","timestamp":1773421198714,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n            <jats:italic>Consomic  rats (SS.BN13), in which chromosome 13 from normotensive inbred Brown  Norway rats from a colony maintained at the Medical College of  Wisconsin (BN\/Mcw) was introgressed into the background of Dahl  salt-sensitive (SS\/Mcw) rats, also maintained in a colony at the  Medical College of Wisconsin, were bred. The present studies  determined the mean arterial pressure (MAP) responses to  salt and renal and peripheral vascular responses to  norepinephrine and angiotensin II; 24-hour  protein excretion and histological analyses  were used to assess renal pathology in rats that received a high salt  (4% NaCl) diet for 4 weeks. MAP of rats measured daily during the  fourth week averaged 170\u00b13.3 mm Hg in SS\/Mcw rats, 119\u00b12.1  mm Hg in SS.BN13 rats, and 103\u00b11.3 mm Hg in BN\/Mcw rats. After  salt depletion, MAP fell an average of 27\u00b14.5 mm Hg in SS\/Mcw  rats, 9\u00b12.6 mm Hg in SS.BN13 rats, and 11\u00b13.0 mm Hg in  BN\/Mcw rats. Protein excretion of SS\/Mcw rats on a high salt diet  averaged 189\u00b130 mg\/24 h, 63\u00b118 mg\/24 h in SS.BN13 rats, and 40\u00b16.4  mg\/24 h in BN\/Mcw rats. Compared with SS.BN13 and BN\/Mcw rats, SS\/Mcw  rats exhibited significantly greater increases of renal vascular  resistance in response to intravenous  norepinephrine and angiotensin II. Severe  medullary interstitial fibrosis and tubular necrosis after  a high salt diet were found consistently in SS\/Mcw rat kidneys  but were largely absent in the SS.BN13 and BN\/Mcw rat kidneys. A  similar degree of glomerular sclerosis was found in both  SS\/Mcw and SS.BN13 rats. In rats fed a 0.4% salt diet, the  glomerular filtration rate of SS\/Mcw rats was significantly  less than that of BN\/Mcw and SS.BN13 rats. These results reveal a  powerful gene, or set of genes, within chromosome 13 of BN\/Mcw rats  that confers protection from the detrimental effects of high salt to  the SS\/Mcw rats.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.2.456","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"456-461","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":153,"title":["Brown Norway Chromosome 13 Confers Protection From High Salt to Consomic Dahl S Rat"],"prefix":"10.1161","volume":"37","author":[{"suffix":"Jr","given":"Allen W.","family":"Cowley","sequence":"first","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Roman","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary L.","family":"Kaldunski","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Dumas","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey G.","family":"Dickhout","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Greene","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard J.","family":"Jacob","sequence":"additional","affiliation":[{"name":"From the Department of Physiology, Medical College of Wisconsin,  Milwaukee."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530440061038"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.4.531"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.15.6.803"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.4.1.20"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.18.3.341"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.18.5.630"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1139\/y84-139"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/4.4.346S"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.1.3.316"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198205273062106"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816040-00001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","unstructured":"Zicha J Kunes J. 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