{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:12:39Z","timestamp":1757700759064},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n            Hypercholesterolemia  and hypertension are both risk factors for end-stage renal disease.  This study was designed to examine whether their coexistence augmented  impairment in renal function and redox status. Regional renal  hemodynamics and function in response to vasoactive  challenges with acetylcholine or sodium nitroprusside were quantified  by using electron-beam computed tomography in pigs after 12 weeks of  either a normal (n=10) or hypercholesterolemic (n=10)  diet, renovascular hypertension (n=7), or combined  hypercholesterolemia+hypertension (n=6). The  hypercholesterolemic and  hypercholesterolemic+hypertensive groups had  significantly increased serum cholesterol levels, whereas  in the hypertensive and  hypercholesterolemic+hypertensive groups, mean  arterial pressure was significantly elevated compared with  the group fed a normal diet. Basal regional renal perfusion and  glomerular filtration rates were similar among the groups.  In response to acetylcholine, cortical perfusion increased in normal  animals (15.6\u00b14.7%,\n            <jats:italic>P<\/jats:italic>\n            =0.002)  but not in hypercholesterolemic or hypertensive animals  (8.0\u00b17.4% and 8.2\u00b15.9%, respectively;\n            <jats:italic>P<\/jats:italic>\n            &gt;0.05). Moreover, in the  hypercholesterolemic+hypertensive group, cortical  perfusion response was further attenuated (2.5\u00b14.8%,\n            <jats:italic>P<\/jats:italic>\n            =0.02) and significantly  different from the group fed a normal diet  (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05). The response to  sodium nitroprusside followed a similar pattern, and the impairment was  augmented in the hypercholesterolemic+hypertensive  group. The functional abnormalities in  hypercholesterolemia or hypertension were  associated with a decrease in systemic and\/or renal tissue levels of  oxygen radical scavengers that was again accentuated in  hypercholesterolemia+hypertension. These  results demonstrate that concurrent  hypercholesterolemia and hypertension have a  greater detrimental effect on renal perfusion responses compared with  hypercholesterolemia or hypertension alone,  associated with a marked pro-oxidant shift in redox status. These  effects may potentially augment renal functional impairment and play a  role in the initiation and progression of renal injury in hypertension  and  atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.2.774","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"774-780","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Combination of Hypercholesterolemia and Hypertension Augments Renal Function Abnormalities"],"prefix":"10.1161","volume":"37","author":[{"given":"Martin","family":"Rodriguez-Porcel","sequence":"first","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James D.","family":"Krier","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Patrick F.","family":"Sheedy","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Carlos","family":"Romero","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Napoli","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Divisions of Hypertension  [J.D.K., L.O.L.] and Cardiovascular Diseases [M.R.-P.,  A.L.]), and Diagnostic Radiology (P.F.S.), and Physiology and Biophysics  (J.C.R.), Mayo Clinic, Rochester, Minn; the Department of Medicine (C.N.),  University of Naples, Naples, Italy; and the Department of Medicine-0682  (C.N.), University of California, San Diego."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00968.x"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.29.1.188"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000168651"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-74-1-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.supp9.45"},{"key":"e_1_3_2_6_2","first-page":"474","volume":"20","year":"2000","unstructured":"Bloch MJ, Pickering T. 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