{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:16:44Z","timestamp":1780078604486,"version":"3.54.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,2]]},"abstract":"<jats:p>\n            We  previously reported increased monocyte\/macrophage infiltration,  reactive oxygen species accumulation, and nuclear factor-\u03baB (NF-\u03baB)  activation in mineralocorticoid (deoxycorticosterone acetate [DOCA])  hypertensive rats. We tested the hypothesis that prolonged antioxidant  administration inhibits superoxide accumulation, lowers blood pressure,  and reduces NF-\u03baB activation in DOCA-salt hypertensive rats. DOCA  rats exhibited a significant increase in systolic blood  pressure compared with sham rats. Aortic rings from DOCA rats exhibited  increased superoxide  (O\n            <jats:sub>2<\/jats:sub>\n            <jats:sup>\u2212<\/jats:sup>\n            )  production compared with sham rats. In addition, the treatment  of DOCA rats with pyrrolidinedithiocarbamate (PDTC) or  4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl (Tempol) caused a  significant decrease in systolic blood pressure and aortic  superoxide accumulation. Monocyte\/macrophage infiltration was  also significantly decreased in DOCA rats treated with PDTC or Tempol  compared with untreated DOCA rats. NF-\u03baB\u2013binding activity was  significantly greater in untreated DOCA rats than in either sham rats  or PDTC- or Tempol-treated DOCA rats. Also, DOCA rats treated with  Tempol exhibited no significant difference in NF-\u03baB\u2013binding activity  compared with sham. These results suggest that antioxidants attenuate  systolic blood pressure, suppress renal NF-\u03baB\u2013binding  activity, and partly alleviate renal monocyte\/macrophage  infiltration in DOCA-salt hypertension.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.2.781","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"781-786","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":162,"title":["Long-Term Antioxidant Administration Attenuates Mineralocorticoid Hypertension and Renal Inflammatory Response"],"prefix":"10.1161","volume":"37","author":[{"given":"Richard A.","family":"Beswick","sequence":"first","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanfang","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawnyetta","family":"Marable","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Catravas","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Hill","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Clinton","family":"Webb","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology (R.C.W.) and Anatomy (W.D.H.) and the  Vascular Biology Center (H.Z., J.D.C.), Medical College of Georgia, Augusta,  Ga; Department of Physiology (R.A.B.), University of Michigan (Ann Arbor); and  Department of Biology (D.M.), Fort Valley State University, Fort Valley, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.67.6.1700933"},{"key":"e_1_3_2_2_2","first-page":"24","volume":"3","year":"1994","unstructured":"Whitworth JA. Studies on the mechanism of glucocorticoid hypertension in humans. Blood. 1994;3:24\u201332.","journal-title":"Blood"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Somers MJ Mavromatis K Galis ZS Harrison DG. Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation. 2000;1722\u20131728.","DOI":"10.1161\/01.CIR.101.14.1722"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.6.1628"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.6.1353"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00296-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704103361506"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_2_9_2","first-page":"H2125","volume":"270","year":"1996","unstructured":"Liu Y, Liu T, McCarron RM, Spatz M, Feuerstein G, Hallenbeck JM, Siren A. Evidence for activation of endothelium and monocytes in hypertensive rats. Am J Physiol. 1996;270:H2125\u2013H2131.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_10_2","first-page":"463","volume":"28","year":"1999","unstructured":"Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med. 1999;28:463\u2013499.","journal-title":"Free Radic Biol Med"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.36.1.142"},{"key":"e_1_3_2_12_2","first-page":"588","volume":"95","year":"1996","unstructured":"Rajagopalan S, Kurx S, Munzel T, Freemaan BA, Griendling KK, Harrison DG. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH\/NADPH oxidase activation: contribution to alteration of vasomotor tone. J Clin Invest. 1996;95:588\u2013593.","journal-title":"J Clin Invest"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.35.1.193"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.6.1487"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1993.tb05850.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.1.424"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02582-8"},{"key":"e_1_3_2_18_2","first-page":"F175","volume":"268","year":"1991","unstructured":"Mitchel JB, Degraff W, Kaufman D, Krishna MC, Samuni A, Finkelstein E, Ahn MS, Hahn SM, Gamson J, Russon A. Inhibition of oxygen dependent radiation-induced damage by nitroxide superoxide dismutase mimetic, tempol. Arch Biochem Biophys. 1991;268:F175\u2013F178.","journal-title":"Arch Biochem Biophys"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229580"},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","unstructured":"Beswick RA Dorrance AM Rajagopalan S Webb RC. NF-\u03baB inhibition lowers blood pressure in mineralocorticoid hypertensive rats. 54th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research Washington DC October 27 2000. Abstract.","DOI":"10.1161\/hyp.36.suppl_1.692"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116491"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.4.898"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.4.2015"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.15.2027"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01061.x"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703284"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00169-8"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.86.5.494"},{"key":"e_1_3_2_29_2","first-page":"1141","volume":"74","year":"1996","unstructured":"Griending KK, Minieri CA, Ollerenshaw JD, Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1996;74:1141\u20131148.","journal-title":"Circ Res"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.33.1.212"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.23.1.3"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.37.2.781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:43:33Z","timestamp":1715539413000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.37.2.781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["10.1161\/01.HYP.37.2.781"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.37.2.781","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]},"assertion":[{"value":"2000-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}