{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:07:13Z","timestamp":1791252433059,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p>Systemic  leptin increases energy expenditure through sympathetic mechanisms,  decreases appetite, and increases arterial pressure. We  tested the hypothesis that the pressor action of leptin is mediated by  the central nervous system. The interaction of dietary salt with leptin  was also studied. Leptin was infused for 2 to 4 weeks into the third  cerebral ventricle of Sprague-Dawley rats. Arterial  pressure was measured by radiotelemetry. To control for the effects of  leptin on body weight, vehicle-treated rats were pair-fed to the leptin  group. Intracerebroventricular infusion  of leptin at 200 ng\/h in salt-depleted rats caused a reduction in food  intake, weight loss, tachycardia, and decreased  arterial pressure. Leptin at 1000 ng\/h caused further  reduction in food intake, weight loss, and tachycardia and  prevented the hypotensive effect of weight loss observed in pair-fed,  vehicle-treated animals.  Intracerebroventricular leptin at 1000  ng\/h in high-salt\u2013fed rats also caused a sustained pressor response  (+3\u00b11 mm Hg), but high-salt intake did not potentiate the  pressor effect of leptin.  Intracerebroventricular leptin  potentiated the pressor effect of air-jet stress.  Intravenous administration of the same dose of leptin (1000  ng\/h) did not change weight or arterial pressure,  suggesting a direct central nervous system action. In contrast, a high  dose of intravenous leptin (18 000 ng\/h) caused weight  loss and prevented the depressor effect of weight loss. In conclusion,  this study demonstrates that high-dose leptin increases  arterial pressure and heart rate through central neural  mechanisms but leptin does not enhance salt sensitivity of  arterial pressure. Leptin appears to oppose the depressor  effect of weight loss.<\/jats:p>","DOI":"10.1161\/01.hyp.37.3.936","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["Leptin Acts in the Central Nervous System to Produce Dose-Dependent Changes in Arterial Pressure"],"prefix":"10.1161","volume":"37","author":[{"given":"Marcelo L. G.","family":"Correia","sequence":"first","affiliation":[{"name":"From the Specialized Center of Research in Hypertension Genetics, the  Cardiovascular Center and Department of Internal Medicine, The University of  Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"From the Specialized Center of Research in Hypertension Genetics, the  Cardiovascular Center and Department of Internal Medicine, The University of  Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William I.","family":"Sivitz","sequence":"additional","affiliation":[{"name":"From the Specialized Center of Research in Hypertension Genetics, the  Cardiovascular Center and Department of Internal Medicine, The University of  Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyn L.","family":"Mark","sequence":"additional","affiliation":[{"name":"From the Specialized Center of Research in Hypertension Genetics, the  Cardiovascular Center and Department of Internal Medicine, The University of  Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Haynes","sequence":"additional","affiliation":[{"name":"From the Specialized Center of Research in Hypertension Genetics, the  Cardiovascular Center and Department of Internal Medicine, The University of  Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979867"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7624776"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/380677a0"},{"key":"e_1_3_2_5_2","first-page":"100","volume":"15","year":"1997","unstructured":"Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. 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Kidney Int. 1996;55:S150\u2013S153.","journal-title":"Kidney Int"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03173-X"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.30.3.619"}],"container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.HYP.37.3.936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:25:08Z","timestamp":1715538308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.37.3.936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["10.1161\/01.HYP.37.3.936"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.37.3.936","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"2000-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}