{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:01:24Z","timestamp":1791118884710,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Dendroaspis  natriuretic peptide (DNP), a recently discovered peptide,  shares structural similarity to the other known natriuretic  peptides, ANP, BNP, and CNP. Studies have reported that DNP is  present in human and canine plasma and atrial  myocardium and increased in plasma of humans with  congestive heart failure (CHF). In addition, synthetic DNP is markedly  natriuretic and diuretic and is a potent  activator of cGMP in normal animals. To date, the ability  of synthetic DNP to improve cardiorenal function in experimental CHF is  unknown. Synthetic DNP was administered intravenously at 10  and 50 ng \u00b7 kg\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7  min\n            <jats:sup>\u22121<\/jats:sup>\n            in dogs (n=7) with severe CHF induced  by rapid ventricular pacing for 10 days at 245 bpm. In  addition, we determined endogenous DNP in normal (n=4) and  failing (n=4) canine atrial and ventricular  myocardium. We report that administration of synthetic DNP  in experimental severe CHF has beneficial  cardiovascular, renal, and humoral properties. First,  DNP in CHF decreased cardiac filling pressures, specifically right  atrial pressure and pulmonary capillary wedge pressure. Second,  DNP increased glomerular filtration rate in association  with natriuresis and diuresis despite a reduction in mean  arterial pressure. Third, DNP increased plasma and urinary  cGMP and suppressed plasma renin activity. Fourth and finally, we  report that DNP immunoreactivity is present in canine atrial and  ventricular myocardium and increased in CHF.  These studies report the acute intravenous actions of  synthetic DNP in experimental severe CHF and suggest that on the basis  of its beneficial properties, DNP may have potential as a new  intravenous agent for the treatment of decompensated  CHF.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.4.1089","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"1089-1094","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":61,"title":["Therapeutic Actions of a New Synthetic Vasoactive and Natriuretic Peptide, Dendroaspis Natriuretic Peptide, in Experimental Severe Congestive Heart Failure"],"prefix":"10.1161","volume":"37","author":[{"given":"Ondrej","family":"Lisy","sequence":"first","affiliation":[{"name":"From the Cardiorenal Research Laboratory, Division of Cardiovascular  Diseases, Departments of Physiology and Internal Medicine, Mayo Clinic and  Foundation, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Lainchbury","sequence":"additional","affiliation":[{"name":"From the Cardiorenal Research Laboratory, Division of Cardiovascular  Diseases, Departments of Physiology and Internal Medicine, Mayo Clinic and  Foundation, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Leskinen","sequence":"additional","affiliation":[{"name":"From the Cardiorenal Research Laboratory, Division of Cardiovascular  Diseases, Departments of Physiology and Internal Medicine, Mayo Clinic and  Foundation, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John C.","family":"Burnett","sequence":"additional","affiliation":[{"name":"From the Cardiorenal Research Laboratory, Division of Cardiovascular  Diseases, Departments of Physiology and Internal Medicine, Mayo Clinic and  Foundation, Rochester, Minn."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"S107","volume":"13","year":"1994","unstructured":"O\u2019Connell JB, Bristow MR. 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