{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:55:25Z","timestamp":1790870125002,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014The  association of sinuses of Valsalva dilatation and aortic  regurgitation with hypertension is disputed, and few  data are available in population-based samples. We explored the  relations of sinuses of Valsalva dilatation and aortic  regurgitation to hypertension and additional clinical  and echocardiographic data in 2096 hypertensive and 361  normotensive participants in the Hypertension Genetic  Epidemiology Network study. Age and body  surface area were used to predict aortic root diameter using published  equations developed from a separated reference population. Aortic  dilatation was defined as measured sinuses of Valsalva diameter  exceeding the 97.5th percentile of the confidence interval of predicted  diameter for age and body size. Aortic dilatation was present in  4.6% of the population. After adjustment for age and body surface  area, mean aortic root diameter was larger in hypertensives with  suboptimal blood pressure control than normotensives or hypertensives  with optimal blood pressure control. In multivariate  models, sinuses of Valsalva diameter was weakly positively related to  diastolic blood pressure and to left  ventricular mass independent of aortic  regurgitation. Subjects with aortic dilatation were  slightly older, were more frequently men, had higher left  ventricular mass, and had lower left  ventricular systolic chamber function independent  of covariates. Sinuses of Valsalva dilatation was independently related  to male gender, aortic valve fibrocalcification, and  echocardiographic wall motion abnormalities but not to  diastolic blood pressure (or history of hypertension in a  separate model). The likelihood of aortic regurgitation  increased with larger aortic root diameter, older age, female gender,  presence of aortic valve fibrocalcification, and lower body mass index  but not hypertension or diabetes. In a subsequent model,  diastolic blood pressure was negatively related to aortic  regurgitation independent of covariates. In a large  population-based sample, sinuses of Valsalva diameter was only mildly  larger in subjects with suboptimally controlled hypertension than in  normotensives or well-controlled hypertensives, which did not result in  differences in prevalence of aortic regurgitation among  groups. Sinuses of Valsalva dilatation was associated with higher left  ventricular mass and lower systolic function, which  may contribute to higher cardiovascular risk in  subjects with aortic root dilatation.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.5.1229","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"1229-1235","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":118,"title":["Aortic Root Dilatation at Sinuses of Valsalva and Aortic Regurgitation in Hypertensive and Normotensive Subjects"],"prefix":"10.1161","volume":"37","author":[{"given":"Vittorio","family":"Palmieri","sequence":"first","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Bella","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna K.","family":"Arnett","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Roman","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Oberman","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Paranicas","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Devereux","sequence":"additional","affiliation":[{"name":"From the Weill Medical College of Cornell University (V.P., J.N.B.,  M.J.R., M.P., R.B.D.), New York, NY; University of Minnesota (D.K.A.),  Minneapolis; University of Alabama at Birmingham (A.O.); Wake Forest  University School of Medicine (D.W.K.), Winston-Salem, NC; University of Utah  School of Medicine (P.N.K.), Salt Lake City; and Washington University Medical  School (D.C.R.), St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.91.3.734"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90430-X"},{"key":"e_1_3_2_3_2","first-page":"1119","volume":"139","year":"1991","unstructured":"Virmani R, Avolio AP, Mergner WJ, Robinowitz M, Herderick EE, Cornhill JF, Guo SY, Liu TH, Ou DY, O\u2019Rourke M. 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