{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:45:17Z","timestamp":1759826717181},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Plasma  levels of adrenomedullin are increased in chronic renal failure. The  significance of this finding is uncertain, because the biological  effects of adrenomedullin in renal impairment are unknown. Therefore,  we studied the effects of adrenomedullin infusion in subjects with  chronic renal impairment. Eight males with IgA nephropathy  and plasma creatinine of 0.19\u00b10.03 mmol\/L (mean\u00b1SEM)  were studied in a vehicle-controlled crossover design. Each subject was  studied twice; subjects were administered either adrenomedullin at a  low dose and then a high dose (2.9 and 5.8 pmol\/kg per minute,  respectively, for 2 hours each) or a 4-hour vehicle control  (Hemaccel), in random order, on day 4 of controlled  metabolic diets. Adrenomedullin infusion achieved plasma  adrenomedullin concentrations in the  pathophysiological range after the low (31.2\u00b15.1  pmol\/L) and high (47.4\u00b14.3 pmol\/L) dose, and plasma cAMP was  increased. Compared with vehicle control, high-dose adrenomedullin  increased peak heart rate (+21.7\u00b13.3 bpm,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) and cardiac output  (+2.9\u00b10.2 L\/min,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) and  lowered both systolic and diastolic blood pressures  by &gt;10 mm Hg (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05).  Plasma renin activity, angiotensin II, and  norepinephrine increased by up to 50% above baseline  levels (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05 for all),  whereas aldosterone and epinephrine were unchanged.  Urinary volume and sodium excretion increased significantly  (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) with low-dose  adrenomedullin, whereas creatinine clearance was stable,  and proteinuria tended to decrease. In subjects with chronic renal  impairment due to IgA  nephropathy,   adrenomedullin infusion lowered blood pressure, stimulated sympathetic  activity and renin release, and caused diuresis and  natriuresis. Adrenomedullin may have a role in modulating blood  pressure and kidney function in renal  disease.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.5.1279","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"1279-1284","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Hypotensive and Natriuretic Actions of Adrenomedullin in Subjects With Chronic Renal Impairment"],"prefix":"10.1161","volume":"37","author":[{"given":"David O.","family":"McGregor","sequence":"first","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Troughton","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Frampton","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin L.","family":"Lynn","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Yandle","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Mark","family":"Richards","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Gary","family":"Nicholls","sequence":"additional","affiliation":[{"name":"From the Cardioendocrine Research Group (R.W.T., C.F., T.Y., A.M.R.,  G.N.) and the Department of Nephrology (D.O.M., K.L.L.), Christchurch  Hospital, Christchurch, New Zealand."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1451"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.61.1.363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117573"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.1.C200"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000189455"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.5.1214"},{"key":"e_1_3_2_7_2","first-page":"1016","volume":"85","year":"2000","unstructured":"Lainchbury JG, Troughton RW, Lewis LK, Yandle TG, Richards AM, Nicholls MG. 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