{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:18:07Z","timestamp":1791494287584,"version":"4.3.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014This  prospective study was designed to compare the captopril suppression  test with the salt-loading approach to confirm the diagnosis of primary  aldosteronism. A total of 49 patients were referred with a presumed  diagnosis of primary aldosteronism. The captopril test was performed in  the morning with patients in the seated position after overnight  fasting. Blood samples for plasma aldosterone were obtained  before captopril administration (25 mg PO) and again 2 hours later.  Patients were then subjected to a high salt diet (300 mmol sodium  per day for 3 days). On the third day, urinary sodium (24 hours) was  measured, and plasma aldosterone levels were measured at  8:00\n            <jats:sc>am<\/jats:sc>\n            (recumbent) and at  noon (standing). Of the 49 patients, 44 had nonsuppressible  aldosterone concentrations with all the clinical  characteristics of primary aldosteronism: 22 patients had surgically  confirmed unique adenoma, and 22 patients had presumed bilateral  hyperplasia. There was a significant correlation between plasma  aldosterone values of salt-loaded patients (mean of 8:00\n            <jats:sc>am<\/jats:sc>\n            and noon results) and  the values 2 hours after captopril administration  (\n            <jats:italic>r<\/jats:italic>\n            =0.8,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01). Plasma  aldosterone cumulative distribution curves in primary  aldosteronism patients (adenoma and hyperplasia) were not significantly  different between the 2 suppression tests. Our results showed that the  captopril suppression test is as effective as sodium loading in  confirming the diagnosis of primary aldosteronism.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.37.6.1440","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"1440-1443","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Captopril Suppression Versus Salt Loading in Confirming Primary Aldosteronism"],"prefix":"10.1161","volume":"37","author":[{"given":"Mohsen","family":"Agharazii","sequence":"first","affiliation":[{"name":"From CHUQ, L\u2019Ho\u0302tel-Dieu de Que\u0301bec Hospital, and  Department of Medicine, Faculty of Medicine, Laval University, Que\u0301bec,  Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Douville","sequence":"additional","affiliation":[{"name":"From CHUQ, L\u2019Ho\u0302tel-Dieu de Que\u0301bec Hospital, and  Department of Medicine, Faculty of Medicine, Laval University, Que\u0301bec,  Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Grose","sequence":"additional","affiliation":[{"name":"From CHUQ, L\u2019Ho\u0302tel-Dieu de Que\u0301bec Hospital, and  Department of Medicine, Faculty of Medicine, Laval University, Que\u0301bec,  Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Lebel","sequence":"additional","affiliation":[{"name":"From CHUQ, L\u2019Ho\u0302tel-Dieu de Que\u0301bec Hospital, and  Department of Medicine, Faculty of Medicine, Laval University, Que\u0301bec,  Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0992-66"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1992.tb00462.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-5-1190"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90891-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340130033011"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62114-4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410180075008"},{"key":"e_1_3_2_8_2","unstructured":"Gordon RD Stowasser M Klemm SA Tunny TJ. Primary aldosteronism and other forms of mineralocorticoid hypertension. In: Swales J ed. Textbook of Hypertension. Oxford UK: Blackwell Scientific; 1994:865\u2013892."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30097-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812173392507"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1971.00310210056004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-57-5-892"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1019037"},{"key":"e_1_3_2_14_2","unstructured":"Wilcox R. Kolmogorov-Smirnov test. In: Armitage P Colton T eds. Encyclopedia of Biostatistics. Chichester UK: John Wiley & Sons; 1998;3:2174\u20132176."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.26.549"},{"key":"e_1_3_2_16_2","first-page":"611","volume":"9","year":"1987","unstructured":"Muratani H, Abe I, Tomita Y, Ueno M, Takishita S, Kawazoe N, Tsuchihashi T, Kawasaki T, Fujishima M. Single oral administration of captopril may not bring an improvement in screening of primary aldosteronism. Clin Exp Hypertens. 1987;9:611\u2013614.","journal-title":"Clin Exp Hypertens"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02252.x"},{"key":"e_1_3_2_18_2","first-page":"1175","volume":"117","year":"1992","unstructured":"Wambach G, Degenhardt S, B\u00f6nner G, Stimpel M, Grimm U, Krone W. The captopril test as a potential improvement in the diagnosis of primary hyperaldosteronism. 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