{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:34:30Z","timestamp":1774355670920,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:p>\n            The angiotensinogen M235T polymorphism has been linked to hypertension and cardiovascular disease. We studied the role of this polymorphism as a risk factor for carotid atherosclerosis and small-vessel disease-related brain abnormalities. A total of 431 randomly selected community-dwelling subjects without clinical evidence for strokes underwent angiotensinogen genotyping and carotid Duplex scanning; 1.5-T brain magnetic resonance imaging (MRI) was done in 396 individuals. At 3-year follow-up, we reexamined 343 and 267 study participants by ultrasound and brain MRI, respectively. Carotid atherosclerosis was graded on a 5-point scale. Small-vessel disease-related brain abnormalities were deep or subcortical white matter lesions or lacunes. Progression of carotid atherosclerosis and MRI findings was rated by direct imaging comparison by 3 independent raters. The M\/M, M\/T, and T\/T genotypes were seen in 20.9%, 52.9%, and 18.1% of subjects, respectively. The M235T polymorphism was neither associated with baseline carotid findings nor with progression of carotid atherosclerosis. There was a trend toward more frequent small-vessel disease-related MRI abnormalities in the T\/T than in the other genotypes at the baseline examination. Progression of brain lesions occurred significantly more commonly in T\/T than in M\/M and M\/T carriers (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001). Logistic regression analysis identified the T\/T genotype (odds ratio, 3.19;\n            <jats:italic>P<\/jats:italic>\n            =0.002) and arterial hypertension (odds ratio, 3.06;\n            <jats:italic>P<\/jats:italic>\n            =0.03) as significant independent predictors of lesion progression. These data suggest that the angiotensinogen T\/T genotype at position 235 is a genetic marker for brain lesions from and progression of small vessel disease but not for extracranial carotid atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.38.1.110","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":34,"title":["Angiotensinogen Polymorphism M235T, Carotid Atherosclerosis, and Small-Vessel Disease-Related Cerebral Abnormalities"],"prefix":"10.1161","volume":"38","author":[{"given":"Reinhold","family":"Schmidt","sequence":"first","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Schmidt","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Fazekas","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lenore J.","family":"Launer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Niederkorn","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kapeller","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Lechner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert M.","family":"Kostner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.S., F.F., K.N., P.K., A.L.), Institute of Medical Biochemistry and Medical Molecular Biology (H.S., G.M.K.), and MRI Center (R.S., F.F., P.K.), Karl-Franzens University, Graz, Austria; and the National Institute on Aging, National Institutes of Health (L.J.L.), Bethesda, Md."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90275-H"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117803"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917010-00003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90115-9"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.25.5.950"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(96)00105-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70226-7"},{"key":"e_1_3_2_8_2","first-page":"681","volume":"9","year":"1995","unstructured":"Barley J, Markus H, Brown M, Carter N. 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