{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:42:33Z","timestamp":1782276153506,"version":"3.54.5"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:p>\n            <jats:italic>\n              <jats:italic>Abstract<\/jats:italic>\n              \u2014\n            <\/jats:italic>\n            \u2014 This study reports the determination of plasma 18-hydroxycortisol (18-OHF) using a new and easy enzyme-linked immunosorbent assay (ELISA) method in primary aldosteronism and compares the values found in essential hypertensives and normotensive controls. In primary aldosteronism, we evaluated usefulness of plasma 18-OHF determination and the dexamethasone suppression test in the diagnosis of glucocorticoid-remediable aldosteronism using the genetic test as the gold standard. We studied 31 primary aldosteronism patients, 101 essential hypertensives, and 102 healthy normotensive controls. The plasma 18-OHF was measured using a biotin-avidin enzyme-linked assay by a new and purified polyclonal antibody. The 18-OHF value in primary aldosteronism was 6.3\u00b18.05 nmol\/L; this value is significantly higher than the value found in essential hypertensives and normotensive controls (2.81\u00b11.42 and 2.70\u00b11.41 nmol\/L, respectively;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0005). In primary aldosteronism, 4 of 31 patients had 18-OHF levels that were 10 times higher than the normal upper limit (2.983 nmol\/L). The dexamethasone suppression test in primary aldosteronism patients was positive (serum aldosterone &lt;4 ng\/dL) in 13 of 31 cases. A chimeric\n            <jats:italic>CYP11B1\/CYP11B2<\/jats:italic>\n            gene was demonstrated in 4 primary aldosteronism patients, corresponding to the same cases that had higher level of 18-OHF. In conclusion, plasma 18-OHF determination by this ELISA method is reliable for detecting glucocorticoid-remediable aldosteronism, and it does so better than the dexamethasone suppression test.\n          <\/jats:p>","DOI":"10.1161\/01.hyp.38.3.688","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:25:31Z","timestamp":1339460731000},"page":"688-691","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Serum 18-Hydroxycortisol in Primary Aldosteronism, Hypertension, and Normotensives"],"prefix":"10.1161","volume":"38","author":[{"given":"Lorena","family":"Mosso","sequence":"first","affiliation":[{"name":"Department of Endocrinology Faculty of Medicine Pontificia Universidad Cato\u0301lica de Chile (L.M., C.F.), Santiago, Chile; Division of Endocrinology, The University of Mississippi Medical Center and the G.V. (Sonny) Montgomery VA Medical Center (C.E.G.-S.), Jackson, Miss; and Harry S. Truman VA Medical Center (M.F.F.), Columbia, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso E.","family":"Go\u0301mez-Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Faculty of Medicine Pontificia Universidad Cato\u0301lica de Chile (L.M., C.F.), Santiago, Chile; Division of Endocrinology, The University of Mississippi Medical Center and the G.V. (Sonny) Montgomery VA Medical Center (C.E.G.-S.), Jackson, Miss; and Harry S. Truman VA Medical Center (M.F.F.), Columbia, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark F.","family":"Foecking","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Faculty of Medicine Pontificia Universidad Cato\u0301lica de Chile (L.M., C.F.), Santiago, Chile; Division of Endocrinology, The University of Mississippi Medical Center and the G.V. (Sonny) Montgomery VA Medical Center (C.E.G.-S.), Jackson, Miss; and Harry S. Truman VA Medical Center (M.F.F.), Columbia, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fardella","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Faculty of Medicine Pontificia Universidad Cato\u0301lica de Chile (L.M., C.F.), Santiago, Chile; Division of Endocrinology, The University of Mississippi Medical Center and the G.V. (Sonny) Montgomery VA Medical Center (C.E.G.-S.), Jackson, Miss; and Harry S. Truman VA Medical Center (M.F.F.), Columbia, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"2218","volume":"258","year":"1982","unstructured":"Chu MD, Ulick S. Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism. 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