{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:21:10Z","timestamp":1790864470568,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1982,11]]},"abstract":"<jats:p>Disruption of the blood-brain barrier may play a major role in the pathogenesis of hypertensive encephalopathy. In this study we determined whether sympathetic nerves to cerebral vessels protect the blood-brain barrier during chronic hypertension. We removed the cervical sympathetic ganglion on one side in 24 stroke-prone hypertensive rats when they were 1 month old. After signs of cerebral dysfunction developed at the mean age of 160 +\/- 5 days (SE), we injected 125I-albumin and Evans blue dye intravenously to evaluate the permeability of the 125I-albumin was 3.53 +\/- 0.83 (brain albumin x 100\/blood albumin) in areas of the cerebrum stained with blue dye and 0.24 +\/- 0.02 in unstained areas (p less than 0.05). We conclude that sympathetic nerves protect the blood-brain barrier against disruption during chronic hypertension and thereby may protect against hypertensive encephalopathy.<\/jats:p>","DOI":"10.1161\/01.hyp.4.6.904","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:22:33Z","timestamp":1339460553000},"page":"904-907","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Sympathetic nerves protect the blood-brain barrier in stroke-prone spontaneously hypertensive rats."],"prefix":"10.1161","volume":"4","author":[{"given":"S","family":"Sadoshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Heistad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.4.6.904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:38:28Z","timestamp":1715539108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.4.6.904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,11]]}},"alternative-id":["10.1161\/01.HYP.4.6.904"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.4.6.904","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,11]]},"assertion":[{"value":"1982-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}