{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:27:32Z","timestamp":1790249252767,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6_pt_3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Hypertension"],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p>To determine the contribution of receptor number and affinity to changes in vascular reactivity to angiotensin II (AII) in hypertensive rats, we have investigated the binding of 125I-AII to a particulate fraction of the rat mesenteric artery of hypertensive rats. In two-kidney, one clip hypertensive rats, receptor concentration (Bmax) was 83 +\/- 13 fmol\/mg and the dissociation constant (Kd) 0.6 +\/- 0.1 nM vs 75 +\/- 5.3 fmol\/mg and 0.6 +\/- 0.1 nM in normotensive controls, although PRA was much higher in the former. Bmax was reduced in these hypertensive rats after sodium depletion, as in normal rats. One-kidney, one clip hypertensive rats (Bmax 88 +\/- 17 fmol\/mg, Kd 0.6 +\/- 0.1 nM) did not differ from uninephrectomized control rats (96 +\/- 9 fmol\/mg, Kd 0.5 +\/- 0.1 nM). In DOCA-salt hypertensive rats, binding capacity was increased (125 +\/- 2 fmol\/mg, Kd 0.7 +\/- 0.0 nM) vs uninephrectomized salt-loaded rats (Bmax 95 +\/- 6 fmol\/mg, Kd 0.6 +\/- 0.1 nM), although PRA was suppressed comparably in both groups. The salt-loaded rats did not differ from uninephrectomized controls drinking water. We conclude that changes in the circulating renin-angiotensin system do not explain all the variations in receptor number in hypertensive rats. Our results suggest a role of mineralocorticoids in the regulation of vascular AII receptors.<\/jats:p>","DOI":"10.1161\/01.hyp.5.6_pt_3.v16","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T13:56:42Z","timestamp":1378389402000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Vascular angiotensin II receptors in renal and DOCA-salt hypertensive rats."],"prefix":"10.1161","volume":"5","author":[{"given":"E L","family":"Schiffrin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F S","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Genest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.HYP.5.6_Pt_3.V16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:38:45Z","timestamp":1715539125000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.HYP.5.6_Pt_3.V16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":0,"journal-issue":{"issue":"6_pt_3","published-print":{"date-parts":[[1983,11]]}},"alternative-id":["10.1161\/01.HYP.5.6_Pt_3.V16"],"URL":"https:\/\/doi.org\/10.1161\/01.hyp.5.6_pt_3.v16","relation":{},"ISSN":["0194-911X","1524-4563"],"issn-type":[{"value":"0194-911X","type":"print"},{"value":"1524-4563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,11]]},"assertion":[{"value":"1983-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}