{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:53:55Z","timestamp":1756994035362},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1964,5]]},"abstract":"<jats:p>A refined, reliable thrombin generation test with good sensitivity for both hypo- and hypercoagulability is described. When serial thrombin generation curves were obtained in cardiac patients subjected to standardized treadmill stress, fluctuations of the clotting system were observed in some and a marked tendency to hypercoagulability in others. The relationship of in vitro hypercoagulability as reflected by thrombin generation to an increased tendency to thrombosis remains to be determined.<\/jats:p>","DOI":"10.1161\/01.res.14.5.436","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:44:49Z","timestamp":1339461889000},"page":"436-446","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Thrombin Generation in Normal Subjects and Cardiac Patients"],"prefix":"10.1161","volume":"14","author":[{"given":"KURT N.","family":"VON KAULLA","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Colorado School of Medicine, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EDITH","family":"VON KAULLA","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Colorado School of Medicine, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.RES.14.5.436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:17:37Z","timestamp":1715537857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.14.5.436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1964,5]]}},"alternative-id":["10.1161\/01.RES.14.5.436"],"URL":"https:\/\/doi.org\/10.1161\/01.res.14.5.436","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,5]]},"assertion":[{"value":"1963-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1964-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}