{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:23:27Z","timestamp":1770485007255,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1965,8]]},"abstract":"<jats:p>\n            The effects of localized acidosis and alkalosis on coronary blood flow, myocardial contractile force, and heart rate were studied in anesthetized, open-chest dogs. Acidosis of the coronary vascular bed was induced by infusion of 5,5-dimethyl-2, 4-oxazolidinedion (DMO) into the total coronary artery inflow, and alkalosis by infusion of tris hydroxymethyl aminomethane (THAM), Na\n            <jats:sub>2<\/jats:sub>\n            CO\n            <jats:sub>3<\/jats:sub>\n            or NaHCO\n            <jats:sub>3<\/jats:sub>\n            . DMO infusion caused an initial slight increase of coronary blood flow, followed by a decrease. The decrease was accompanied by and attributed to a moderate to marked decrease of myocardial contractile force and bradycardia. THAM and Na\n            <jats:sub>2<\/jats:sub>\n            CO\n            <jats:sub>3<\/jats:sub>\n            infusion caused a marked increase of coronary blood flow, associated with a decrease of coronary oxygen A-V difference, indicating coronary vasodilation. A slight to moderate increase of myocardial contractile force but little or no change in heart rate was noted. NaHCO\n            <jats:sub>3<\/jats:sub>\n            infusion caused changes similar to those induced by DMO but of smaller magnitude. It was suggested that the direct effects of DMO and NaHCO\n            <jats:sub>3<\/jats:sub>\n            are attributable to intracellular acidosis, whereas those of THAM and Na\n            <jats:sub>2<\/jats:sub>\n            CO\n            <jats:sub>3<\/jats:sub>\n            are attributable to intracellular alkalosis.\n          <\/jats:p>","DOI":"10.1161\/01.res.17.2.114","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:44:49Z","timestamp":1339461889000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Effects of Changes in Coronary Blood pH on the Heart"],"prefix":"10.1161","volume":"17","author":[{"given":"HSUEH-HWA","family":"WANG","sequence":"first","affiliation":[{"name":"Departments of Pharmacology and Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RONALD L.","family":"KATZ","sequence":"additional","affiliation":[{"name":"Departments of Pharmacology and Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.RES.17.2.114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:31:38Z","timestamp":1715538698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.17.2.114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1965,8]]}},"alternative-id":["10.1161\/01.RES.17.2.114"],"URL":"https:\/\/doi.org\/10.1161\/01.res.17.2.114","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,8]]},"assertion":[{"value":"1965-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1965-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}