{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:10:47Z","timestamp":1758280247756},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1968,7]]},"abstract":"<jats:p>Oxidative and phosphorylative activities were measured polarographically in mitochondria isolated from the right and left ventricles of normal and chronically stressed dog hearts. Chronic myocardial stress was produced experimentally by surgical procedures (combined tricuspid insufficiency and pulmonary stenosis, pulmonary insufficiency, aortic stenosis, aortic insufficiency, Potts's anastomosis) and by inducing thyrotoxicosis. Experimental stress periods ranged from 332 to 608 days. Some of the dogs had overt symptoms of congestive heart failure at the time they were killed.<\/jats:p>\n          <jats:p>Mitochondria isolated from the stressed hearts had abnormally high values for oxidative activity and respiratory control ratios when incubated in the presence of malate-pyruvate. In the presence of succinate, they had either normal or slightly elevated values for oxidative activity and respiratory control ratios. No differences were found between mitochondria from normal and stressed hearts with regard to the efficiency (ADP\/O) of oxidative phosphorylation. Estimates of mitochondrial protein per gram of myocardial tissue indicated that the stressed hearts contained normal amounts of mitochondria. The results of this study suggest that the mitochondrial oxidative and phosphorylative capabilities of the chronically stressed myocardium are not impaired.<\/jats:p>","DOI":"10.1161\/01.res.23.1.87","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:44:49Z","timestamp":1339461889000},"page":"87-97","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Oxidative Phosphorylation in Mitochondria Isolated from Chronically Stressed Dog Hearts"],"prefix":"10.1161","volume":"23","author":[{"given":"CLINTON D.","family":"STONER","sequence":"first","affiliation":[{"name":"Heart Biochemistry Research Laboratory of the Cardiovascular Service, Division of Thoracic Surgery, and Departments of Surgery and Physiological Chemistry, Ohio State University College of Medicine, Columbus, Ohio 43210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MEHDI M.","family":"RESSALLAT","sequence":"additional","affiliation":[{"name":"Heart Biochemistry Research Laboratory of the Cardiovascular Service, Division of Thoracic Surgery, and Departments of Surgery and Physiological Chemistry, Ohio State University College of Medicine, Columbus, Ohio 43210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HOWARD D.","family":"SIRAK","sequence":"additional","affiliation":[{"name":"Heart Biochemistry Research Laboratory of the Cardiovascular Service, Division of Thoracic Surgery, and Departments of Surgery and Physiological Chemistry, Ohio State University College of Medicine, Columbus, Ohio 43210"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.RES.23.1.87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:37:09Z","timestamp":1715542629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.23.1.87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1968,7]]}},"alternative-id":["10.1161\/01.RES.23.1.87"],"URL":"https:\/\/doi.org\/10.1161\/01.res.23.1.87","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,7]]},"assertion":[{"value":"1968-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1968-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}