{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:29:25Z","timestamp":1778275765841,"version":"3.51.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1979,6]]},"abstract":"<jats:p>To determine whether acute chloride depletion per se stimulates renin, we produced selective chloride depletion without sodium depletion in rats by peritoneal dialysis (PD) against 0.15 M NaHCO3 or 0.15 M NaNO3. Control rats were dialyzed against 0.15 M NaCl. Plasma renin activity (PRA) was measured before (PRA1) and 105 minutes after (PRA2) PD. Plasma volume was expanded after PD by infusion of salt-free albumin and was measured immediately after PRA2 by [131I]albumin. In experiment 1, rats were prepared on a normal diet. PRA2 (7.0 +\/- 1.0 ng\/ml per hr, mean +\/- SEM) was increased (P less than 0.05) over PRA1 (4.7 +\/- 0.7 ng\/ml per hr) in Cl-depleted but not in control rats (PRA1 = 5.3 +\/- 0.7, PRA2 = 6.1 +\/- 0.7, P = NS). In experiment 2, to produce greater chloride depletion, all rats were prepared for 2 weeks on a low salt diet. PRA2 (47 +\/- 5 ng\/ml per hr) was increased as compared to PRA1 (24 +\/- 2 ng\/ml per hr, P less than 0.005) in the Cl-depleted group but not in the control group (PRA1 = 24 +\/- 3, PRA2 = 27 +\/- 6 ng\/ml per hr, P = NS). Serum potassium and final plasma volume were slightly but not significantly lower than controls in these Cl-depleted rats. To exclude an additive effect of these two stimuli for renin, in experiment 2a we infused chloride-depleted rats with three times as much albumin as controls and with KHCO3, 100 mEq\/liter. Despite volume expansion and potassium loading, PRA2 (41 +\/- 6 ng\/ml per hr) was significantly elevated as compared to PRA1 (25 +\/- 4 ng\/ml per hr, P less than 0.01). Since acute metabolic alkalosis also was present in all Cl-depleted renin-stimulated rats, an additional group (2b) was dialyzed against 0.15 M NaNO3; final plasma arterial pH (7.43) was not different from controls (7.42). Nevertheless, PRA2 levels again were higher (36 +\/- 6 ng\/ml per hr, P less than 0.05) as compared to PRA1 (23 +\/- 4 ng\/ml per hr). In all experiments, arterial blood pressure, glomerular filtration rate, and filtered sodium load were not different. Free water reabsorption was lower in Cl-depleted than in control rats. We conclude that acute selective chloride depletion per se is a potent stimulus for renin release.<\/jats:p>","DOI":"10.1161\/01.res.44.6.815","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:16:17Z","timestamp":1339460177000},"page":"815-821","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Stimulation of renin by acute selective chloride depletion in the rat."],"prefix":"10.1161","volume":"44","author":[{"given":"H E","family":"Abboud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Luke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Galla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T A","family":"Kotchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.RES.44.6.815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:22:51Z","timestamp":1715541771000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.44.6.815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1979,6]]}},"alternative-id":["10.1161\/01.RES.44.6.815"],"URL":"https:\/\/doi.org\/10.1161\/01.res.44.6.815","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,6]]},"assertion":[{"value":"1979-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}