{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:22:34Z","timestamp":1756992154270},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1957,7]]},"abstract":"<jats:p>The reduction of arterial pressure in anesthetized dogs following the injection of ganglion-blocking agents is dependent primarily upon a reduction in arterial vasomotor activity and secondarily upon a reduction in venous return associated with an increase in vascular capacity. When venous return is maintained at control levels, the administration of the blocking agents of this study invariably produce a decrease in total peripheral resistance (TPR). Ordinarily in the intact animal such a decrease in TPR is not observed due to a marked reduction in cardiac output which produces a secondary increase in TPR. The results of this study further suggests that the venous and arterial systems may differ in their sensitivity to the effects of ganglion-blocking agents.<\/jats:p>","DOI":"10.1161\/01.res.5.4.444","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:13:47Z","timestamp":1339460027000},"page":"444-450","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Role of Venous Return in the Cardiovascular Response Following Injection of Ganglion-Blocking Agents"],"prefix":"10.1161","volume":"5","author":[{"given":"JOSEPH H.","family":"TRAPOLD","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, La."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan G.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, La."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Louisiana State University, School of Medicine, New Orleans, La."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.RES.5.4.444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T19:29:49Z","timestamp":1715542189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.5.4.444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1957,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1957,7]]}},"alternative-id":["10.1161\/01.RES.5.4.444"],"URL":"https:\/\/doi.org\/10.1161\/01.res.5.4.444","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1957,7]]},"assertion":[{"value":"1957-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1957-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}