{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:26:32Z","timestamp":1768465592670,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            We conducted the present study to determine if pharmacologically recruitable flow reserve was present during ischemia in unanesthetized dogs studied in the absence of adrenergic activation. Microsphere measurements of regional perfusion at reduced coronary pressures in a distal circumflex region subjected to intracoronary adenosine infusion (0.265 mg\/min IC) were compared with measurements in a proximal circumflex region where pressure was reduced but flow was being autoregulated normally. Ischemia began when coronary pressure was reduced below 40 mm Hg. At a coronary pressure of 28\u00b11 (mean\u00b1SEM) mm Hg, subendocardial flow with autoregulation intact was 0.59\u00b10.05 mL \u00b7 min \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            and similar to that in the region receiving adenosine, which averaged 0.61\u00b10.05 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            (\n            <jats:italic>P<\/jats:italic>\n            =NS). Although adenosine increased subepicardial flow from 0.81\u00b10.05 to 1.16\u00b10.09 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 g\n            <jats:sup>\u22121<\/jats:sup>\n            (\n            <jats:italic>P<\/jats:italic>\n            &lt;.001), the magnitude of the increase was minimal when coronary pressure fell to a level that caused subepicardial flow during autoregulation to be reduced below resting values. These results demonstrate that the substantially lower autoregulatory break point found in unanesthetized dogs studied in the basal state reflects the ability of intrinsic autoregulatory mechanisms to match local vasodilator reserve to that recruitable pharmacologically. This contrasts with the presence of pharmacologically recruitable subendocardial flow reserve in anesthetized animals and is most likely related to a low level of circulating catecholamines and lack of sympathetic activation in unanesthetized animals studied under basal conditions.\n          <\/jats:p>","DOI":"10.1161\/01.res.76.6.1079","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:47:05Z","timestamp":1339462025000},"page":"1079-1087","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Adenosine-Recruitable Flow Reserve Is Absent During Myocardial Ischemia in Unanesthetized Dogs Studied in the Basal State"],"prefix":"10.1161","volume":"76","author":[{"suffix":"Jr","given":"John M.","family":"Canty","sequence":"first","affiliation":[{"name":"From the Departments of Medicine and Physiology at the State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Veterans Administration Medical Center, Buffalo, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Thomas P.","family":"Smith","sequence":"additional","affiliation":[{"name":"From the Departments of Medicine and Physiology at the State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Veterans Administration Medical Center, Buffalo, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.71.2.3965177"},{"key":"e_1_3_2_2_2","first-page":"H403","volume":"248","year":"1985","unstructured":"Aversano T, Becker LC. Persistence of coronary vasodilator reserve despite functionally significant flow reduction. Am J Physiol. 1985;248:H403-H411.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_3_2","first-page":"H638","volume":"249","year":"1985","unstructured":"Pantely GA, Bristow JD, Swenson LJ, Ladley HD, Johnson WB, Anselone CG. Incomplete coronary vasodilation during myocardial ischemia in swine. Am J Physiol. 1985;249:H638-H647.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_4_2","first-page":"H276","volume":"250","year":"1986","unstructured":"Grattan MT, Hanley FL, Stevens MB, Hoffman JIE. Transmural coronary flow reserve patterns in dogs. 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