{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:24:47Z","timestamp":1778235887747,"version":"3.51.4"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            Hypertension-induced cardiac hypertrophy is associated with alterations in ventricular action potentials. To understand molecular mechanisms underlying this electrical abnormality, expression of cardiac voltage-gated K\n            <jats:sup>+<\/jats:sup>\n            channel subunit genes was examined in ventricles of renovascular hypertensive rats. While generating a rat Kv4.3 probe, we discovered a previously unreported 19\u2013amino acid insertion in the C-terminal intracellular region of the channel subunit. RNase protection assays indicated that this novel isoform is predominant in rat lung and heart. Effects of renovascular hypertension were then determined by using renal artery clipping models: two-kidney, one clip (2K-1C) rats, a model of high-renin hypertension with a normal plasma volume, and one-kidney, one clip (1K-1C) rats, a model of normal renin with a raised plasma volume. Expression of Kv4.2 and Kv4.3 mRNAs was diminished by &gt;50% in ventricles of 2K-1C rats; however, no changes in the expression of Kv1.2, Kv1.4, Kv1.5, Kv2.1, or KvLQT1 mRNAs were detected. Similar downregulation of Kv4.2 and Kv4.3 mRNAs was detected in 1K-1C rats. Chronic administration of captopril, an angiotensin-converting enzyme inhibitor, blocked the development of hypertension and the suppression of Kv4 subfamily channel mRNA expression in 2K-1C rats. Furthermore, captopril administration to sham-operated rats significantly increased Kv4.2 mRNA. These results indicate that renovascular hypertension causes specific reductions in Kv4 subfamily channel mRNA expression and that this effect is likely to be mediated primarily by an increase in cardiac afterload.\n          <\/jats:p>","DOI":"10.1161\/01.res.81.4.533","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:47:05Z","timestamp":1339462025000},"page":"533-539","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Decreased Expression of Kv4.2 and Novel Kv4.3 K\n            <sup>+<\/sup>\n            Channel Subunit mRNAs in Ventricles of Renovascular Hypertensive Rats"],"prefix":"10.1161","volume":"81","author":[{"given":"Koichi","family":"Takimoto","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danqing","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Hershman","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin K.","family":"Jackson","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin S.","family":"Levitan","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology (K.T., D.L., K.M.H., E.S.L.) and the Center for Clinical Pharmacology (P.L., E.K.J.), University of Pittsburgh (Pa)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199109010-00002"},{"key":"e_1_3_2_2_2","first-page":"189","volume":"5","year":"1996","unstructured":"Johnson DB, Dell\u2019Italia LJ. Cardiac hypertrophy and failure in hypertension. Curr Opin Nephrol Hypertens. 1996;5:189-191.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072893"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)88586-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.64.4.2522834"},{"key":"e_1_3_2_6_2","first-page":"H1413","volume":"255","year":"1988","unstructured":"Kleinman RB, Houser SR. Calcium currents in normal and hypertrophied isolated feline ventricular myocytes. Am J Physiol. 1988;255:H1413-H1442.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199306000-00005"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019807"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.2.7518363"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00073-9"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585941"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.8.1180"},{"key":"e_1_3_2_13_2","first-page":"H935","volume":"260","year":"1991","unstructured":"Xu W, Best PM. Decreased transient outward K+ current in ventricular myocytes from acromegalic rats. Am J Physiol. 1991;260:H935-H942.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.79.3.461"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.5.1798"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.2.8033339"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.77.2.361"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.79.4.659"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.80.2.261"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90299-F"},{"key":"e_1_3_2_21_2","first-page":"A308","volume":"70","year":"1996","unstructured":"Yeola SW, Snyder DJ. Functional and pharmacological correspondence between Kv4.2 and cardiac transient outward currents. Biophys J. 1996;70:A308. Abstract.","journal-title":"Biophys J"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.4.1516"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6309"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.11.6272"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00120-X"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90191-S"},{"key":"e_1_3_2_27_2","first-page":"287","volume":"1","year":"1993","unstructured":"Attardi B, Takimoto K, Gealy R, Severns C, Levitan ES. Glucocorticoid induced up-regulation of a pituitary K+ channel mRNA in vitro and in vivo. Receptors Channels. 1993;1:287-293.","journal-title":"Receptors Channels"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.75.6.7955140"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(96)00095-0"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.79.4.669"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116751"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0196-17"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31421-2"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/384080a0"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/384078a0"},{"key":"e_1_3_2_36_2","unstructured":"Pickering TJ. Renovascular hypertension. In: Laragh JH Brenner BM eds. Pathophysiology Diagnosis and Management. New York NY: Raven Press Publishers; 1990:1539-1559."},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08483.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/340642a0"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(90)90146-7"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.9.3932"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4603"},{"key":"e_1_3_2_43_2","doi-asserted-by":"crossref","unstructured":"de Miera EV-S Moreno H Fruhling D Kentos C Rudy B. Cloning of ShIII (Shaw-like) cDNAs encoding a novel high voltage-activating TEA-sensitive type A K+ channel. Proc R Soc Lond B Biol Sci. 1992;B:9-18.","DOI":"10.1098\/rspb.1992.0036"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74340-3"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.RES.81.4.533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:52:22Z","timestamp":1715547142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.81.4.533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1161\/01.RES.81.4.533"],"URL":"https:\/\/doi.org\/10.1161\/01.res.81.4.533","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"1997-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}