{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:18:42Z","timestamp":1790054322224,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1998,3,9]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014One possible mechanism for neurohumoral activation after myocardial infarction may be the generation of an immune response against cardiac self-antigens. We hypothesize that if there is a T cell\u2013mediated reaction to self-antigens, the transfer of splenic lymphocytes from postinfarct rats into syngeneic rats with normal hearts should result in a T cell\u2013mediated autoimmune myocarditis in the healthy syngeneic rats. Rats were killed 6 weeks after coronary ligation. Splenocytes from animals with large and small infarcts were purified from spleens, activated with concanavalin A, and injected in varying doses into normal syngeneic rats. These recipient rats were killed 6 weeks later, and histopathological studies were performed. Our results demonstrate in vivo evidence of lymphocyte-mediated myocardial injury by adoptive transfer of sensitized lymphocytes from rats who developed congestive heart failure after acute myocardial infarction. The amount of infiltrate and necrosis in the recipient rats appeared directly related to the size of the infarct from the donor rats. This suggests that larger infarcts lead to a greater inflammatory response as well as a greater propensity for alteration of cardiac surface antigens or the emergence of previously sequestered antigens. None of the other organs (kidney, liver, lung, or brain) had evidence of infiltrates. Two-dimensional echocardiography did not reveal systolic dysfunction. This study provides direct evidence of autoimmune myocardial injury produced by adoptive transfer of concanavalin A\u2013activated splenocytes after myocardial infarction. We propose that neurohumoral activation early in the postinfarction period triggers a series of specific inflammatory and immunological events that lead to formation of specific clones of T cells. When these are activated and transferred into normal rats, cardiac-specific cellular infiltration occurs, occasionally accompanied by myocardial necrosis. This model should help to further explore the link between neurohumoral activation after myocardial infarction and the subsequent immune alterations that might be associated with the development and\/or progression of congestive heart failure. Additionally, this might be a useful model in which to study other immune-mediated cardiomyopathies.\n          <\/jats:p>","DOI":"10.1161\/01.res.82.4.458","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:47:05Z","timestamp":1339462025000},"page":"458-463","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Experimental Autoimmune Myocarditis Produced by Adoptive Transfer of Splenocytes After Myocardial Infarction"],"prefix":"10.1161","volume":"82","author":[{"given":"Alan","family":"Maisel","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cesario","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Baird","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalees","family":"Rehman","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"Haghighi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Carter","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Division of Cardiology, and Department of Pathology, Veterans Affairs Medical Center and University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.44.4.428047"},{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.6.843"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.49.3.7261261"},{"key":"e_1_3_1_4_2","unstructured":"Francis GS McDonald KM Cohn JN. Neurohumoral activation in preclinical heart failure: remodeling and the potential for intervention. Circulation. 1993;87(suppl IV):IV-90\u2013IV-96."},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.4.3280156"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.3.2548769"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/1071-9164(95)90004-7"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00123-H"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.148.11.3441"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007263230405"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-1229(05)80001-7"},{"key":"e_1_3_1_12_2","unstructured":"Maisch B. Immunological mechanisms in human cardiac injury. In: Spry CJF ed. Immunology and Molecular Biology of Cardiovascular Disease. London England: MRP Press; 1987:225\u2013252."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.85.5.1572047"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(83)90535-0"},{"key":"e_1_3_1_15_2","first-page":"423","volume":"57","year":"1984","unstructured":"De Scheerder I, Wulfrank D, Van Renterghem L, Sabbe L, Robbrecht D, Clement D, Derom F, Plum J, Verdonk G. Association of anti-heart antibodies and circulating immune complexes in the post-pericardiotomy syndrome. Clin Exp Immunol. 1984;57:423\u2013428.","journal-title":"Clin Exp Immunol"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059831"},{"key":"e_1_3_1_17_2","first-page":"1279","volume":"160","year":"1956","unstructured":"Dressler W. A post-myocardial infarction syndrome. JAMA. 1956;160:1279\u20131301.","journal-title":"JAMA"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000232109"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.59.070190.004031"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(89)90410-9"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.64.2.2536302"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114888"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.64.1.2535798"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(89)90027-1"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.RES.82.4.458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:51:22Z","timestamp":1715547082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.82.4.458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,9]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,3,9]]}},"alternative-id":["10.1161\/01.RES.82.4.458"],"URL":"https:\/\/doi.org\/10.1161\/01.res.82.4.458","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3,9]]},"assertion":[{"value":"1997-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}