{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:55:47Z","timestamp":1770965747415,"version":"3.50.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1999,11,26]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Smooth muscle cell (SMC) proliferation that results in neointima formation is implicated in the pathogenesis of atherosclerotic plaques and accounts for the high rates of restenosis that occur after percutaneous transluminal coronary angioplasty, a widespread treatment for coronary artery disease. Endothelial lesions trigger intense proliferative signals to the SMCs of the subintima, stimulating their reentry into the cell cycle from a resting G\n            <jats:sub>0<\/jats:sub>\n            state, resulting in neointima formation and vascular occlusion. Cellular proliferation is negatively controlled by growth-regulatory or tumor-suppressor genes, or both, such as the retinoblastoma gene family members (\n            <jats:italic>RB\/p105, p107, RB2\/p130<\/jats:italic>\n            ). In the present study, we show that\n            <jats:italic>RB2\/p130<\/jats:italic>\n            inhibited SMC proliferation in vitro and in vivo. We used the rat carotid artery model of restenosis to demonstrate that adenovirus-mediated localized arterial transduction of\n            <jats:italic>RB2\/p130<\/jats:italic>\n            at the time of angioplasty significantly reduced neointimal hyperplasia and prevented restenosis. Furthermore, the ability of pRb2\/p130 to block proliferation correlated with its ability to bind and sequester the E2F family of transcription factors, which are important mediators of cell cycle progression. These results imply that\n            <jats:italic>RB2\/p130<\/jats:italic>\n            could be an important target for vascular gene therapy.\n          <\/jats:p>","DOI":"10.1161\/01.res.85.11.1032","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:47:05Z","timestamp":1339462025000},"page":"1032-1039","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Adenoviral\n            <i>RB2\/p130<\/i>\n            Gene Transfer Inhibits Smooth Muscle Cell Proliferation and Prevents Restenosis After Angioplasty"],"prefix":"10.1161","volume":"85","author":[{"given":"Pier Paolo","family":"Claudio","sequence":"first","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Fratta","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicia","family":"Farina","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candace M.","family":"Howard","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Stassi","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Numata","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Pacilio","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Davis","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Lavitrano","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Volpe","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Trimarco","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Giordano","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Condorelli","sequence":"additional","affiliation":[{"name":"From the Department of Pathology Anatomy and Cell Biology (P.P.C., C.M.H., C.P., A.G.) and Kimmel Cancer Center (G.C.), Thomas Jefferson University, Philadelphia, Pa; Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali (P.P.C.), Universita\u0301 degli Studi di Napoli \u201cFederico II,\u201d Napoli, Italy; IRCCS \u201cNeuromed\u201d Institute (L.F., M.V., B.T.), Pozzilli (IS), Italy; Rangos Research Center (G.S.), University of Pittsburgh, Pittsburgh, Pa; Department of Surgical, Anatomical and Oncological..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"208","volume":"49","year":"1983","unstructured":"Clowes AW, Reidy MA, Clowes MM. 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