{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:35:42Z","timestamp":1791012942633,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[1999,9,3]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Chronic atrial fibrillation (AF) is characterized by decreased atrial contractility, shortened action potential duration, and decreased accommodation of action potential duration to changes in activation rate. Studies on experimental animal models of AF implicate a reduction in L-type Ca\n            <jats:sup>2+<\/jats:sup>\n            current (\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            ) density in these changes. To evaluate the effect of AF on human\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            , we compared\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            in atrial myocytes isolated from 42 patients in normal sinus rhythm at the time of cardiac surgery with that of 11 chronic AF patients.\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            was significantly reduced in the myocytes of patients with chronic AF (mean \u22123.35\u00b10.5 pA\/pF versus \u22129.13\u00b11.0 pA\/pF in the controls), with no difference between groups in the voltage dependence of activation or steady-state inactivation. Although\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            was lower in myocytes from the chronic AF patients, their response to maximal \u03b2-adrenergic stimulation was not impaired. Postoperative AF frequently follows cardiac surgery. Half of the patients in the control group (19\/38) of this study experienced postoperative AF. Whereas chronic AF is characterized by reduced atrial\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            , the patients with the greatest\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            had an increased incidence of postoperative AF, independent of patient age or diagnosis. This observation is consistent with the concept that calcium overload may be an important factor in the initiation of AF. The reduction in functional\n            <jats:italic>I<\/jats:italic>\n            <jats:sub>Ca<\/jats:sub>\n            density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload.\n          <\/jats:p>","DOI":"10.1161\/01.res.85.5.428","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:47:05Z","timestamp":1339462025000},"page":"428-436","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":439,"title":["Atrial L-Type Ca\n            <sup>2+<\/sup>\n            Currents and Human Atrial Fibrillation"],"prefix":"10.1161","volume":"85","author":[{"given":"David R.","family":"Van Wagoner","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L.","family":"Pond","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Lamorgese","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra S.","family":"Rossie","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Nerbonne","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (D.R.V.W., M.L.) and Kaufman Center for Heart Failure and Department of Cardiothoracic Surgery (P.M.M.), The Cleveland Clinic Foundation, Cleveland, Ohio; Department of Biochemistry (A.L.P., S.S.R.), Purdue University, West Lafayette, Ind; and Department of Molecular Biology and Pharmacology (J.M.N.), Washington University School of Medicine, St. Louis, Mo."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00299-3"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.54.5.975472"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(82)90032-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.1986.tb06676.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.7.1954"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.80.6.772"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.81.4.512"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.95.7.1945"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.5.1542"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00036-X"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00008-X"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00045-0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198207223070401"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","unstructured":"Bristow MR. Changes in myocardial and vascular receptors in heart failure. J Am Coll Cardiol. 1993;22(4 suppl A):61A\u201371A.","DOI":"10.1016\/0735-1097(93)90465-D"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.4.548"},{"key":"e_1_3_2_16_2","first-page":"H227","volume":"272","year":"1997","unstructured":"Li GR, Nattel S. Properties of human atrial ICa at physiological temperatures and relevance to action potential. Am J Physiol. 1997;272:H227\u2013H235.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.1.H301"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.92.7.1954"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.9.3157"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.96.10.3710"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00712.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199801000-00004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0416"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/039139889001300506"},{"key":"e_1_3_2_25_2","first-page":"H886","volume":"273","year":"1997","unstructured":"Bassani RA, Bassani JW, Lipsius SL, Bers DM. Diastolic SR Ca efflux in atrial pacemaker cells and Ca-overloaded myocytes. Am J Physiol. 1997;273:H886\u2013H892.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(97)01215-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(97)80010-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.98.7.719"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.RES.85.5.428","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:40:59Z","timestamp":1715546459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.85.5.428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9,3]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,9,3]]}},"alternative-id":["10.1161\/01.RES.85.5.428"],"URL":"https:\/\/doi.org\/10.1161\/01.res.85.5.428","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9,3]]},"assertion":[{"value":"1999-03-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}