{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:24:19Z","timestamp":1791329059171,"version":"4.3.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2000,2,4]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. To further study the in vivo function of VEGF-B, we have generated\n            <jats:italic>Vegfb<\/jats:italic>\n            knockout mice (\n            <jats:italic>Vegfb<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            ). Unlike\n            <jats:italic>Vegfa<\/jats:italic>\n            knockout mice, which die during embryogenesis,\n            <jats:italic>Vegfb<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            mice are healthy and fertile. Despite appearing overtly normal,\n            <jats:italic>Vegfb<\/jats:italic>\n            <jats:sup>\u2212\/\u2212<\/jats:sup>\n            hearts are reduced in size and display vascular dysfunction after coronary occlusion and impaired recovery from experimentally induced myocardial ischemia. These findings reveal a role for VEGF-B in the development or function of coronary vasculature and suggest potential clinical use in therapeutic angiogenesis. The full text of this article is available at http:\/\/www.circresaha.org.\n          <\/jats:p>","DOI":"10.1161\/01.res.86.2.e29","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:52:16Z","timestamp":1339462336000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":243,"title":["Mice Lacking the Vascular Endothelial Growth Factor-B Gene (\n            <i>Vegfb<\/i>\n            ) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia"],"prefix":"10.1161","volume":"86","author":[{"given":"Daniela","family":"Bellomo","sequence":"first","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Headrick","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginters U.","family":"Silins","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Paterson","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penny S.","family":"Thomas","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gartside","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Mould","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian M.","family":"Cahill","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Tonks","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean M.","family":"Grimmond","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Townson","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wells","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Little","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret C.","family":"Cummings","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Hayward","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham F.","family":"Kay","sequence":"additional","affiliation":[{"name":"From the QCF Transgenic Laboratory and Human Genetics Laboratory, Joint Experimental Oncology Program, the Queensland Institute of Medical Research (D.B., G.U.S., C.A.P., M.G., A.M., M.M.C., I.D.T., S.M.G., S.T., N.K.H., G.F.K.), and the Department of Pathology, University of Queensland (M.C.C.), Brisbane, Australia; Griffith University (J.P.H.), Gold Coast Campus, Southport, Australia; Department of Cardiothoracic Surgery (P.S.T.), Imperial College School of Medicine, National Heart and Lung..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6.2.124"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2576"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.32.19310"},{"key":"e_1_3_2_4_2","first-page":"1","volume":"237","year":"1999","unstructured":"Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol. 1999;237:1\u201330.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_5_2","first-page":"41","volume":"237","year":"1999","unstructured":"Eriksson U, Alitalo K. Structure, expression and receptor-binding properties of novel vascular endothelial growth factors. Curr Top Microbiol Immunol. 1999;237:41\u201357.","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9355"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11709"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.30.21217"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/380439a0"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/380435a0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/8379"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/376066a0"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9349"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0372"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(98)00040-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199905)215:1<12::AID-DVDY3>3.0.CO;2-N"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.10.4303"},{"key":"e_1_3_2_18_2","first-page":"54","volume":"5","year":"1994","unstructured":"Oberdick J, Wallace JD, Lewin A, Smeyne RJ. Transgenic expression to monitor dynamic organization of neuronal development: use of the Escherichia coli lacZ gene product, B-galactosidase. Neuroprotocols. 1994;5:54\u201362.","journal-title":"Neuroprotocols"},{"key":"e_1_3_2_19_2","first-page":"H917","volume":"275","year":"1998","unstructured":"Headrick JP, McKirdy JC, Willis RJ. Functional and metabolic effects of extracellular magnesium in normoxic and ischemic myocardium. Am J Physiol. 1998;275:H917\u2013H929.","journal-title":"Am J Physiol"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177010899"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.46.4.6444555"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000159155"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092010117"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0068"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.6.1149"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00789442"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.71.4.1516163"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373844"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.82.2.186"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1991.261.2.H469"},{"key":"e_1_3_2_31_2","first-page":"H100","volume":"268","year":"1995","unstructured":"Meissner A, Morgan JP. Contractile dysfunction and abnormal Ca2+ modulation during postischemic reperfusion in rat heart. Am J Physiol. 1995;268:H100\u2013H111.","journal-title":"Am J Physiol"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.RES.86.2.e29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:47:46Z","timestamp":1715546866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.86.2.e29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2,4]]}},"alternative-id":["10.1161\/01.RES.86.2.e29"],"URL":"https:\/\/doi.org\/10.1161\/01.res.86.2.e29","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2,4]]},"assertion":[{"value":"1999-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-12-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-02-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}