{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:11:41Z","timestamp":1789866701560,"version":"4.0.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2000,8,18]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014Host genetic responses that characterize enteroviral myocarditis have not yet been determined. The injurious and inflammatory process in heart muscle may reflect host responses of benefit to the virus and ultimately result in congestive heart failure and dilated cardiomyopathy. On the other hand, host responses within the myocardium may secure the host against acute or protracted damage. To investigate the nature of modified gene expression in comparison with normal tissue, mRNA species were assessed in myocardium using cDNA microarray technology at days 3, 9, and 30 after infection. Of 7000 clones initially screened, 169 known genes had a level of expression significantly different at 1 or more postinfection time points as compared with baseline. The known regulated genes were sorted according to their functional groups and normalized expression patterns and, subsequently, interpreted in the context of viremic, inflammatory, and healing phases of the myocarditic process.\n          <\/jats:p>","DOI":"10.1161\/01.res.87.4.328","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:52:16Z","timestamp":1339462336000},"page":"328-334","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Host Gene Regulation During Coxsackievirus B3 Infection in Mice"],"prefix":"10.1161","volume":"87","author":[{"given":"Lydia A.","family":"Taylor","sequence":"first","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Carthy","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decheng","family":"Yang","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Saad","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Schreiner","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence W.","family":"Stanton","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce M.","family":"McManus","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Research Laboratory (L.A.T., C.M.C., D.Y., K.S., D.W., B.M.M.), Department of Pathology and Laboratory Medicine, University of British Columbia, St. Paul\u2019s Hospital, Vancouver, Canada, and SCIOS, Inc (G.S., L.W.S.), Sunnyvale, Calif."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(08)60783-6"},{"key":"e_1_3_2_2_2","unstructured":"Grist NR Reid D. Epidemiology of viral infections of the heart. In: Smith KM Lauffer MA eds. Viral Infections in the Heart. London UK: Edward Arnold; 1993."},{"key":"e_1_3_2_3_2","first-page":"425","volume":"101","year":"1980","unstructured":"Woodruff JF. Viral myocarditis: a review. Am J Pathol. 1980;101:425\u2013484.","journal-title":"Am J Pathol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.136.5.1846"},{"key":"e_1_3_2_5_2","first-page":"163","volume":"18","year":"1988","unstructured":"McManus BM, Gauntt CJ, Cassling RS. Immunopathologic basis of myocardial injury. Cardiovasc Clin. 1988;18:163\u2013184.","journal-title":"Cardiovasc Clin"},{"key":"e_1_3_2_6_2","first-page":"691","volume":"76","year":"1997","unstructured":"Huber SA. Coxsackievirus-induced myocarditis is dependent on distinct immunopathogenic responses in different strains of mice. Lab Invest. 1997;76:691\u2013701.","journal-title":"Lab Invest"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/clin.1993.1113"},{"key":"e_1_3_2_8_2","first-page":"55","volume":"64","year":"1991","unstructured":"Chow LH, Gauntt CJ, McManus BM. Differential effects of myocarditic variants of Coxsackievirus B3 in inbred mice: a pathologic characterization of heart tissue damage. Lab Invest. 1991;64:55\u201364.","journal-title":"Lab Invest"},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","unstructured":"Chow LH Gauntt CJ McManus BM. Early cellular infiltrates in coxsackievirus B3 murine myocarditis. In: Schultheiss H-P ed. New Concepts in Viral Heart Disease: Virology Immunology and Clinical Management. Berlin Germany; 1988.","DOI":"10.1007\/978-3-642-73610-0_20"},{"key":"e_1_3_2_10_2","first-page":"643","volume":"73","year":"1992","unstructured":"Gomez RM, Castagnino CG, Berria MI. Extracellular matrix remodelling after coxsackievirus B3-induced murine myocarditis. Int J Exp Pathol. 1992;73:643\u2013653.","journal-title":"Int J Exp Pathol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.84.6.704"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/4434"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.11.8841-8845.1997"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.86.9.939"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5398.83"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/5013"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10614"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.709-717.1999"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0065"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)80051-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1683"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203298"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/20959"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00131-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1143"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.3.H993"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(200001)182:1<33::AID-JCP4>3.0.CO;2-5"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(90)90380-7"},{"key":"e_1_3_2_29_2","unstructured":"Lehninger AL Nelson DL Cox MM. Principles of Biochemistry. New York: Worth Publishers; 1993."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(97)00075-6"},{"key":"e_1_3_2_31_2","first-page":"587","volume":"15","year":"1999","unstructured":"Dhalla NS, Golfman L, Takeda S, Takeda N, Nagano M. Evidence for the role of oxidative stress in acute ischemic heart disease: a brief review. Can J Cardiol. 1999;15:587\u2013593.","journal-title":"Can J Cardiol"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003950050055"},{"key":"e_1_3_2_33_2","first-page":"17","volume":"1","year":"1998","unstructured":"Sack MN, Kelly DP. The energy substrate switch during development of heart failure: gene regulatory mechanisms. Int J Mol Med. 1998;1:17\u201324.","journal-title":"Int J Mol Med"},{"key":"e_1_3_2_34_2","first-page":"291","volume":"17","year":"1998","unstructured":"Zanssen S, Molnar M, Buse G, Schroder JM. Mitochondrial cytochrome b gene deletion in Kearns-Sayre syndrome associated with a subclinical type of peripheral neuropathy. Clin Neuropathol. 1998;17:291\u2013296.","journal-title":"Clin Neuropathol"},{"key":"e_1_3_2_35_2","first-page":"190","volume":"13","year":"1998","unstructured":"DiMauro S, Hirano M. Mitochondria and heart disease. Curr Opin Cardiol. 1998;13:190\u2013197.","journal-title":"Curr Opin Cardiol"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411706"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.0044"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19990101)20:4\/5<689::AID-ELPS689>3.0.CO;2-J"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421003"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00824.x"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.RES.87.4.328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:57:45Z","timestamp":1715547465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.RES.87.4.328"}},"subtitle":["Assessment by Microarrays"],"short-title":[],"issued":{"date-parts":[[2000,8,18]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8,18]]}},"alternative-id":["10.1161\/01.RES.87.4.328"],"URL":"https:\/\/doi.org\/10.1161\/01.res.87.4.328","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,18]]},"assertion":[{"value":"2000-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}