{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:43:30Z","timestamp":1774323810461,"version":"3.50.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2001,2,2]]},"abstract":"<jats:p>\n            <jats:italic>Abstract<\/jats:italic>\n            \u2014An inward rectifier potassium current, Kir, has been identified in cerebral and coronary resistance vessels, where it is considered to be an important determinant of resting membrane potential (RMP) and to play a role in blood flow regulation. We investigated the functional role of Kir in the renal afferent arteriole using the in vitro\u2013perfused hydronephrotic rat kidney. Increasing external KCl from 5 to 15 mmol\/L induced afferent arteriolar vasodilation. This response was inhibited by 10 to 100 \u03bcmol\/L Ba\n            <jats:sup>2+<\/jats:sup>\n            , concentrations selective for blockade of Kir, and by chloroethylclonidine (100 \u03bcmol\/L) but was not blocked by glibenclamide (10 \u03bcmol\/L) or ouabain (3 mmol\/L). Reducing external KCl from 5 to 1.5 mmol\/L to enhance rectification of Kir caused vasoconstriction at low renal arterial pressure (40 mm Hg) and vasodilation during myogenic vasoconstriction (120 mm Hg), suggesting that this current dominates RMP at low perfusion pressures. When administered to kidneys perfused at 40 mm Hg renal arterial pressure, 30 \u03bcmol\/L Ba\n            <jats:sup>2+<\/jats:sup>\n            elicited afferent arteriolar depolarization, reducing RMP from \u221247\u00b12 to \u221234\u00b12 mV (n=10,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001), and vasoconstriction, reducing diameters from 14.5\u00b11 to 10.9\u00b10.8 \u03bcm (n=10,\n            <jats:italic>P<\/jats:italic>\n            =0.0016). Although Ba\n            <jats:sup>2+<\/jats:sup>\n            reduced resting diameter, blockade of Kir did not prevent myogenic signaling in this vessel. Our findings thus demonstrate the presence of Kir in rat renal afferent arterioles and suggest that this current is an important determinant of RMP in situ.\n          <\/jats:p>","DOI":"10.1161\/01.res.88.2.152","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:52:16Z","timestamp":1339462336000},"page":"152-158","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Functional Evidence for an Inward Rectifier Potassium Current in Rat Renal Afferent Arterioles"],"prefix":"10.1161","volume":"88","author":[{"given":"Lisa","family":"Chilton","sequence":"first","affiliation":[{"name":"From the Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodger","family":"Loutzenhiser","sequence":"additional","affiliation":[{"name":"From the Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.2.546"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.5.C1363"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021527"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012374"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012344"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021318"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00237-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.2.425"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1968.48.4.688"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.4.C799"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Cole WC Cl\u00e9ment-Chomienne O. 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