{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:05:34Z","timestamp":1791155134098,"version":"4.1.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2001,2,16]]},"abstract":"<jats:p><jats:italic>Abstract<\/jats:italic>\u2014The B<jats:sub>1<\/jats:sub>type receptor of bradykinin (Bk B<jats:sub>1<\/jats:sub>R) is believed to be physiologically inert but highly inducible by inflammatory mediators and tissue damage. To explore the potential participation of the Bk B<jats:sub>1<\/jats:sub>R in blood pressure (BP) regulation, we studied mice with deleted Bk B<jats:sub>2<\/jats:sub>R gene with induced experimental hypertension, either salt-dependent (subtotal nephrectomy with 0.5% NaCl as drinking water) or renin\/angiotensin-dependent (renovascular 2-kidney\u20131-clip). Compared with the wild-type controls, the B<jats:sub>2<\/jats:sub>R gene knockout mice had a higher baseline BP (109.7\u00b11.1 versus 101.1\u00b11.3 mm Hg,<jats:italic>P<\/jats:italic>=0.002), developed salt-induced hypertension faster (in 19.3\u00b12.3 versus 27.7\u00b12.4 days,<jats:italic>P<\/jats:italic>=0.024), and had a more severe end point BP (148\u00b13.7 versus 133\u00b13.1 mm Hg,<jats:italic>P<\/jats:italic>&lt;0.05). On the contrary, renovascular hypertension developed to the same extent (149.7\u00b14.3 versus 148\u00b13.6 mm Hg) and in the same time frame (14\u00b12.2 versus 14\u00b12.1 days). A bolus infusion of a selective B<jats:sub>1<\/jats:sub>R antagonist at baseline produced a significant hypertensive response (by 11.4\u00b12 mm Hg) in the knockout mice only. Injection of graded doses of a selective B<jats:sub>1<\/jats:sub>R agonist produced a dose-dependent hypotensive response in the knockout mice only. Assessment of tissue expression of B<jats:sub>1<\/jats:sub>R and B<jats:sub>2<\/jats:sub>R genes by reverse transcription\u2013polymerase chain reaction techniques revealed significantly higher B<jats:sub>1<\/jats:sub>R mRNA levels in the B<jats:sub>2<\/jats:sub>R knockout mice at all times (normotensive baseline and hypertensive end points). At the hypertensive end points, there was always an increase in B<jats:sub>1<\/jats:sub>R gene expression over the baseline values. This increase was significant in cardiac and renal tissues in all hypertensive wild-type mice but only in the clipped kidney of the renovascular knockout mice. The B<jats:sub>2<\/jats:sub>R gene expression in the wild-type mice remained unaffected by experimental manipulations. These results confirm the known vasodilatory and natriuretic function of the Bk B<jats:sub>2<\/jats:sub>R; they also indicate that in its absence, the B<jats:sub>1<\/jats:sub>R can become upregulated and assume some of the hemodynamic properties of the B<jats:sub>2<\/jats:sub>R. Furthermore, they indicate that experimental manipulations to produce hypertension also induce upregulation of the B<jats:sub>1<\/jats:sub>R, but not the B<jats:sub>2<\/jats:sub>R, in cardiac and renal tissues.<\/jats:p>","DOI":"10.1161\/01.res.88.3.275","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T00:52:16Z","timestamp":1339462336000},"page":"275-281","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":117,"title":["Vasoactive Potential of the B<sub>1<\/sub>Bradykinin Receptor in Normotension and Hypertension"],"prefix":"10.1161","volume":"88","author":[{"given":"Irena","family":"Duka","sequence":"first","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kintsurashvili","sequence":"additional","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Gavras","sequence":"additional","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado","family":"Johns","sequence":"additional","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Bresnahan","sequence":"additional","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haralambos","family":"Gavras","sequence":"additional","affiliation":[{"name":"From the Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Mass."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.333"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.35.6.820"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108749"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)90382-5"},{"key":"e_1_3_2_5_2","first-page":"869","volume":"10","year":"1992","unstructured":"Hilme E, Herlitz H, Gyzander E, Hansson H. 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