{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:27:26Z","timestamp":1762673246715},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Acute vertebrobasilar occlusion remains a disease with a high mortality even after treatment by local intra-arterial fibrinolysis. Adjunctive treatment with platelet glycoprotein IIb\/IIIa receptor inhibitors such as abciximab may facilitate recanalization and improve the neurological outcome. Results after treatment of 3 patients by combined intravenous abciximab and local intra-arterial tissue plasminogen activator (tPA) are reported.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Case Descriptions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Treatment was performed within 6 hours of stroke onset. Angiography revealed embolic occlusion of the basilar artery in 2 patients and atherothrombotic occlusion at the vertebrobasilar junction in 1 patient. Therapy consisted of intravenous abciximab bolus administration (0.25 mg\/kg) followed by 12-hour infusion therapy (0.125 \u03bcg\/kg per minute) and local intra-arterial thrombolysis with tPA (10 mg\/h). Heparin was only applied for catheter flushing (500 IU\/h). The patient with the atherothrombotic occlusion was treated with additional percutaneous transluminal angioplasty and stenting. Complete recanalization of the basilar artery occurred in 2 patients, whose conditions improved clinically to functional independence. In the third patient only partial recanalization was seen, with only slight clinical improvement. This patient died of cardiac failure 2 months later. Besides a subtle subarachnoid hemorrhage (n=1), no intracranial or extracranial bleeding complication was observed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            The combination of glycoprotein IIb\/IIIa receptor inhibitor with local intra-arterial tPA might be a promising therapy for patients with acute vertebrobasilar occlusion. Further studies are necessary to define the clinical benefit and the bleeding rate of this new pharmacological approach.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000014247.70674.7f","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"1424-1427","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Acute Basilar Artery Occlusion Treated With Combined Intravenous Abciximab and Intra-arterial Tissue Plasminogen Activator"],"prefix":"10.1161","volume":"33","author":[{"given":"Bernd","family":"Eckert","sequence":"first","affiliation":[{"name":"From the Departments of Neuroradiology (B.E., C.K., H.Z.) and Neurology (G.T., J.R.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Koch","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (B.E., C.K., H.Z.) and Neurology (G.T., J.R.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go\u0308tz","family":"Thomalla","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (B.E., C.K., H.Z.) and Neurology (G.T., J.R.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Roether","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (B.E., C.K., H.Z.) and Neurology (G.T., J.R.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herrmann","family":"Zeumer","sequence":"additional","affiliation":[{"name":"From the Departments of Neuroradiology (B.E., C.K., H.Z.) and Neurology (G.T., J.R.), University Hospital Hamburg-Eppendorf, Hamburg, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/69.2.73"},{"key":"e_1_3_2_2_2","first-page":"545","volume":"137","year":"1981","unstructured":"Labauge R, Pages M, Marty-Double C, Blard J, Boukobza M, Salvaing P. Occlusion du tronc basilaire. Rev Neurol (Paris). 1981; 137: 545\u2013571.","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.10.3176080"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199909000-00025"},{"key":"e_1_3_2_5_2","unstructured":"Eckert B Kucinski T Pfeiffer G Groden C Zeumer H. Endovascular therapy of acute vertebrobasilar occlusion: early treatment onset as the most important factor. Cerebrovasc Dis. 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