{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:22:21Z","timestamp":1790936541813,"version":"4.1.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background and Purpose<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            Severe perinatal asphyxia is an important cause of brain injury in the newborn infant. We examined early events after hypoxic ischemia (HI) in the 7-day-old mouse brain by MRI and related them to long-term functional effects and histopathology in the same animals at 4 to 5 weeks of age.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            HI was induced in 7-day-old CD1 mice by exposure to 8% oxygen for 30 minutes after occlusion of the left common carotid artery. The resulting unilateral focal lesion was evaluated in vivo by MRI (T2 maps and apparent diffusion coefficient maps) at 3, 6, and 24 hours and 5 days after hypoxia. Locomotion and sensorimotor function were analyzed after 3 weeks. Four weeks after HI, the mice were killed, and cresyl violet\u2013stained brain sections were examined morphologically.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Results<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            A decrease in apparent diffusion coefficient values in cortex on the affected side was found at 3 hours after HI. T2 values were significantly increased after 6 hours and remained so for 5 days. Maximal size of the lesion was attained at 3 to 6 hours after HI and declined thereafter. Animals with MRI-detected lesions had decreased forward locomotion, performed worse than controls in the beam-walking test, and showed a unilateral hypotrophy in the cresyl violet\u2013stained brain sections 4 weeks later.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions<\/jats:italic>\n                <\/jats:bold>\n                \u2014\n              <\/jats:italic>\n            <\/jats:bold>\n            The temporal progression of the damage after HI in 7-day-old mice differs from that of the adult brain as judged by MRI. The early lesions detected by MRI were related to functional impairments for these mice in near-adult life.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000014608.78503.db","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:16:47Z","timestamp":1027898207000},"page":"1405-1410","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["MRI Evaluation and Functional Assessment of Brain Injury After Hypoxic Ischemia in Neonatal Mice"],"prefix":"10.1161","volume":"33","author":[{"given":"Ulrika","family":"A\u030ade\u0301n","sequence":"first","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Dahlberg","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil B.","family":"Fredholm","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ju","family":"Lai","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengguan","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u0308rje","family":"Bjelke","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pharmacology, Karolinska Institute (U.A\u030a., V.D., B.B.F.), Department of Clinical Neuroscience, MR Center, Karolinska Institute, Karolinska Hospital (L-J. L., Z.C., B.B.), and Department of Woman and Child Health, Astrid Lindgrens Barnsjukhus (U.A\u030a.), Stockholm, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"Volpe JJ. Neurology of the Newborn. 4th ed. Philadelphia Pa: WB Saunders Co; 2001: 1\u2013912."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199602000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)63260-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(96)00006-1"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-21-09192.1999"},{"key":"e_1_3_2_6_2","unstructured":"\u00c5d\u00e9n U. Adenosine Receptors in the Immature Brain With Special Reference to Their Role in Hypoxic Ischemia [thesis]. Stockholm Sweden: Karolinska Institutet."},{"key":"e_1_3_2_7_2","first-page":"85","volume":"422","year":"1997","unstructured":"Hagberg H, Bona E, Gilland E, Puka-Sundvall M. Hypoxia-ischaemia model in the 7-day-old rat: possibilities and shortcomings. Acta Paediatr Suppl. 1997; 422: 85\u201388.","journal-title":"Acta Paediatr Suppl"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199005000-00007"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00892-0"},{"key":"e_1_3_2_11_2","first-page":"1435","volume":"18","year":"1997","unstructured":"Ginsberg MD. The new language of cerebral ischemia. AJNR Am J Neuroradiol. 1997; 18: 1435\u20131445.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7100929"},{"key":"e_1_3_2_13_2","first-page":"1","volume":"21","year":"2001","unstructured":"Kim J-H, Perugini M, Austin JD, Vezina P. Previous exposure to amphetamine enhances the subsequent locomotor response to a D1 dopamine receptor agonist when glutamate reuptake is inhibited. 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San Diego Calif: Academic Press Inc; 1997."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.6.1741643"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199909000-00008"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199707000-00009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.7.1752"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1174"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12870"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360110"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.11.2281"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(95)00248-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199711000-00021"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90842-H"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00262-2"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000014608.78503.DB","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:50:07Z","timestamp":1715547007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000014608.78503.DB"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["10.1161\/01.STR.0000014608.78503.DB"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000014608.78503.db","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,5]]},"assertion":[{"value":"2001-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}