{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T13:20:51Z","timestamp":1794576051701,"version":"4.9.1"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Although patterns of stroke occurrence and mortality have been well studied, few epidemiological data are available regarding the clinical characteristics of stroke events.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We evaluated hospitalized stroke events reported in the Atherosclerosis Risk in Communities (ARIC) Study to describe the clinical characteristics of incident stroke. Confirmed stroke cases (n=474) were evaluated for stroke symptoms (headache, vertigo, gait disturbance, convulsions) and stroke signs (hemianopia, diplopia, speech deficits, paresis, paresthesia\/sensory deficits) and their univariate associations with race, sex, and stroke subtype.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Over 9.2 years of follow-up, 402 (85%) ischemic and 72 (15%) hemorrhagic strokes occurred. Frequency of stroke symptoms (95% CIs) were as follows: headache (27.4%; 23.4% to 31.4%), gait disturbance (10.8%; 7.9% to 13.6%), convulsions (4.4%; 2.6% to 6.3%), and vertigo (2.1%; 0.8% to 3.4%). Speech deficits occurred in 24.0% (20.2% to 27.9%), hemianopia in 14.6% (11.4% to 17.7%), and diplopia in 5.5% (3.4% to 7.5%) of cases. Most cases involved paresis (81.6%; 78.1% to 85.1%), while fewer cases experienced sensory deficits (44.5%; 40.0% to 49.0%). Blacks were more likely than whites to experience paresis (85.4% versus 78.2%;\n            <jats:italic>P<\/jats:italic>\n            =0.044). Men were more likely than women to experience a gait disturbance (14.4% versus 6.7%;\n            <jats:italic>P<\/jats:italic>\n            =0.007). Persons with hemorrhagic strokes had a higher proportion of headaches (55.6% versus 22.4%;\n            <jats:italic>P<\/jats:italic>\n            =0.001) and convulsions (11.1% versus 3.2%;\n            <jats:italic>P<\/jats:italic>\n            =0.003) than those with ischemic events, while speech and sensory deficits were more common in ischemic strokes (26.1% versus 12.5%,\n            <jats:italic>P<\/jats:italic>\n            =0.013, and 49.0% versus 19.4%,\n            <jats:italic>P<\/jats:italic>\n            =0.001, respectively).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            We present epidemiological data concerning the clinical characteristics of incident stroke in a population-based cohort. Although minor differences by race, sex, and stroke subtype were observed, data from additional follow-up are required to confirm observed variations.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000035286.87503.31","type":"journal-article","created":{"date-parts":[[2002,10,31]],"date-time":"2002-10-31T22:43:22Z","timestamp":1036104202000},"page":"2718-2721","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":316,"title":["Characterization of Incident Stroke Signs and Symptoms"],"prefix":"10.1161","volume":"33","author":[{"given":"Saif S.","family":"Rathore","sequence":"first","affiliation":[{"name":"From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn (S.S.R.); Division of Neurology, Department of Medicine, School of Medicine (A.R.H.), and Department of Epidemiology, School of Public Health (H.A.T., W.D.R.), University of North Carolina at Chapel Hill; and Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert R.","family":"Hinn","sequence":"additional","affiliation":[{"name":"From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn (S.S.R.); Division of Neurology, Department of Medicine, School of Medicine (A.R.H.), and Department of Epidemiology, School of Public Health (H.A.T., W.D.R.), University of North Carolina at Chapel Hill; and Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawton S.","family":"Cooper","sequence":"additional","affiliation":[{"name":"From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn (S.S.R.); Division of Neurology, Department of Medicine, School of Medicine (A.R.H.), and Department of Epidemiology, School of Public Health (H.A.T., W.D.R.), University of North Carolina at Chapel Hill; and Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman A.","family":"Tyroler","sequence":"additional","affiliation":[{"name":"From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn (S.S.R.); Division of Neurology, Department of Medicine, School of Medicine (A.R.H.), and Department of Epidemiology, School of Public Health (H.A.T., W.D.R.), University of North Carolina at Chapel Hill; and Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne D.","family":"Rosamond","sequence":"additional","affiliation":[{"name":"From the Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn (S.S.R.); Division of Neurology, Department of Medicine, School of Medicine (A.R.H.), and Department of Epidemiology, School of Public Health (H.A.T., W.D.R.), University of North Carolina at Chapel Hill; and Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, Md (L.S.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","unstructured":"2002 Heart and Stroke Statistical Update. Dallas Tex: American Heart Association; 2002."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.23.11.1440701"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.7.1367"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009445"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.2.415"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.4.736"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.3.660"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.10.2105"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.9.8073452"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.2.284"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000035286.87503.31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:01:12Z","timestamp":1715547672000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000035286.87503.31"}},"subtitle":["Findings From the Atherosclerosis Risk in Communities Study"],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1161\/01.STR.0000035286.87503.31"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000035286.87503.31","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]},"assertion":[{"value":"2002-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}