{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T02:10:34Z","timestamp":1784686234769,"version":"3.55.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Conventional contrast-enhanced angiography is the gold standard for visualization of the vascular tree supplied by the major cerebral arteries and assessment of collateral flow. Thus far, however, no methods are available to assess the actual flow territories of the individual cerebral arteries. In the present study, we evaluate a noninvasive arterial spin labeling MRI method for selective mapping of the flow territories of the left and right internal carotid arteries and posterior circulation (basilar artery and vertebral arteries).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            A spatially selective labeling approach, regional perfusion imaging, was developed on the basis of selective slab inversion of the arterial water with a pulsed arterial spin labeling sequence. The selectivity of this method was demonstrated.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Regional perfusion imaging enables assessment of the perfusion territories of the major cerebral arteries. With selective labeling of an internal carotid artery, signal is present in both the ipsilateral anterior cerebral artery and ipsilateral middle cerebral artery flow territory. With labeling of the basilar artery, perfusion-weighted signal is symmetrically present in both posterior cerebral artery flow territories. Cerebral blood flow values measured with regional perfusion imaging in the complete hemisphere (40.1 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 100 g\n            <jats:sup>\u22121<\/jats:sup>\n            tissue), white matter (22.1 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 100 g\n            <jats:sup>\u22121<\/jats:sup>\n            tissue), and gray matter (65.8 mL \u00b7 min\n            <jats:sup>\u22121<\/jats:sup>\n            \u00b7 100 g\n            <jats:sup>\u22121<\/jats:sup>\n            tissue) are in agreement with data in the literature.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            We present the first imaging method capable of evaluating both quantitatively and qualitatively the flow territories of the individual brain-feeding arteries in vivo.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000120312.26163.ec","type":"journal-article","created":{"date-parts":[[2004,3,2]],"date-time":"2004-03-02T01:54:06Z","timestamp":1078192446000},"page":"882-887","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":143,"title":["Flow Territory Mapping of the Cerebral Arteries With Regional Perfusion MRI"],"prefix":"10.1161","volume":"35","author":[{"given":"Jeroen","family":"Hendrikse","sequence":"first","affiliation":[{"name":"From the Department of Radiology, University Medical Center, Utrecht, the Netherlands (J.H., J.v.d.G.); Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.L., P.C.M.v.Z., X.G.); and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (H.L., P.C.M.v.Z., X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van der Grond","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, University Medical Center, Utrecht, the Netherlands (J.H., J.v.d.G.); Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.L., P.C.M.v.Z., X.G.); and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (H.L., P.C.M.v.Z., X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, University Medical Center, Utrecht, the Netherlands (J.H., J.v.d.G.); Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.L., P.C.M.v.Z., X.G.); and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (H.L., P.C.M.v.Z., X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.M.","family":"van Zijl","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, University Medical Center, Utrecht, the Netherlands (J.H., J.v.d.G.); Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.L., P.C.M.v.Z., X.G.); and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (H.L., P.C.M.v.Z., X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Golay","sequence":"additional","affiliation":[{"name":"From the Department of Radiology, University Medical Center, Utrecht, the Netherlands (J.H., J.v.d.G.); Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Md (H.L., P.C.M.v.Z., X.G.); and F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Md (H.L., P.C.M.v.Z., X.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1957.02330390017003"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.1.128"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199907000-00001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000086465.41263.06"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1073"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(99)00050-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10228"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199906)41:6<1093::AID-MRM4>3.0.CO;2-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10475"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199903)9:3<454::AID-JMRI14>3.0.CO;2-B"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.2000.2107"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10525"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1492(199604)9:2<79::AID-NBM399>3.0.CO;2-4"},{"key":"e_1_3_2_14_2","first-page":"783","volume":"43","year":"1997","unstructured":"Barth M, Moser E. 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