{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:36:37Z","timestamp":1793914597744,"version":"4.8.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background\u2014<\/jats:italic>\n            <\/jats:bold>\n            Appropriate design of molecular genetic studies of ischemic stroke requires an understanding of the genetic epidemiology of stroke. However, there are no published population-based data on heritability of aetiological subtypes of ischemic stroke, confounding by heritability of other vascular risk factors, or the relationship between heritability and age of onset.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We studied family history of stroke (FHx\n            <jats:sub>Stroke<\/jats:sub>\n            ) and of myocardial infarction (FHx\n            <jats:sub>MI<\/jats:sub>\n            ) in first-degree relatives in 2 population-based studies (Oxford Vascular Study [OXVASC]; Oxfordshire Community Stroke Project [OCSP]). We related FHx\n            <jats:sub>Stroke<\/jats:sub>\n            and FHx\n            <jats:sub>MI<\/jats:sub>\n            to subtype of ischemic stroke, age, and the presence of vascular risk factors and performed a systematic review of all studies of FHx\n            <jats:sub>Stroke<\/jats:sub>\n            by stroke subtype.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            In our population-based studies and in 3 hospital-based studies, FHx\n            <jats:sub>Stroke<\/jats:sub>\n            was least frequent in cardioembolic stroke (OR=0.74, 95%CI=0.58 to 0.95,\n            <jats:italic>P<\/jats:italic>\n            =0.02) but was equally frequent in the other subtypes. In OXVASC and OCSP, FHx\n            <jats:sub>Stroke<\/jats:sub>\n            (\n            <jats:italic>P<\/jats:italic>\n            =0.02), FHx\n            <jats:sub>MI<\/jats:sub>\n            (\n            <jats:italic>P<\/jats:italic>\n            =0.04), and FHx of either (\n            <jats:italic>P<\/jats:italic>\n            =0.006) were associated with stroke at a younger age. Only FHx\n            <jats:sub>Stroke<\/jats:sub>\n            was associated with previous hypertension (OR=1.59, 95%CI=1.08 to 2.35,\n            <jats:italic>P<\/jats:italic>\n            =0.02). FHx\n            <jats:sub>MI<\/jats:sub>\n            was more frequent in large-artery stroke (OR=1.63, 95%CI=0.99 to 2.69,\n            <jats:italic>P<\/jats:italic>\n            =0.05).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Consistent results in our population-based studies and previous hospital-based studies suggest that inclusion bias is not a major problem for studies of the genetic epidemiology of stroke. Molecular genetic studies might be best targeted at non-cardioembolic stroke and younger patients. However, genetic susceptibility to hypertension may account for a significant proportion of the heritability of ischemic stroke.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000121646.23955.0f","type":"journal-article","created":{"date-parts":[[2004,3,9]],"date-time":"2004-03-09T01:35:15Z","timestamp":1078796115000},"page":"819-824","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["Heritability of Ischemic Stroke in Relation to Age, Vascular Risk Factors, and Subtypes of Incident Stroke in Population-Based Studies"],"prefix":"10.1161","volume":"35","author":[{"given":"U.G.R.","family":"Schulz","sequence":"first","affiliation":[{"name":"From the Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Flossmann","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220202"},{"key":"e_1_3_2_2_2","first-page":"1-143","volume":"33","year":"1974","unstructured":"Okamoto K, Yamori Y, Nagakoa A. Establishment of the stroke-prone spontaneously hypertensive rat (SHR). Circ Res. 1974; 33\/34: 1-143\u20131-153.","journal-title":"Circ Res"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.9.1784"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000107187.84390.aa"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000069723.17984.fd"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(01)00691-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.12.2939"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000021409.16314.16"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000079818.08343.8c"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.11.1373"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070107"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115175"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.3.550"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.5.1091"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)93206-O"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114224"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.84.3.1884448"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.2.487"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000121646.23955.0f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:49:31Z","timestamp":1715550571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000121646.23955.0f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1161\/01.STR.0000121646.23955.0f"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000121646.23955.0f","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"2003-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-01-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-03-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}