{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T08:39:44Z","timestamp":1792485584421,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    CADASIL causes repeated ischemic strokes leading to subcortical vascular dementia. The purpose of this study was to assess whether cerebral blood flow (CBF) and regional cerebral metabolic rates of glucose (rCMR\n                    <jats:sub>gluc<\/jats:sub>\n                    ) in CADASIL patients are affected in early adulthood.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    CBF and rCMR\n                    <jats:sub>gluc<\/jats:sub>\n                    were examined with positron emission tomography in correlation with magnetic resonance imaging (MRI) in 14 adult (19 to 41 years) CADASIL patients with the\n                    <jats:italic>Notch3<\/jats:italic>\n                    R133C mutation. Seven patients had experienced transient ischemic attack and 3 had experienced \u22651 strokes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The mean CBF in the CADASIL patients was significantly lower in both frontal (\n                    <jats:italic>P<\/jats:italic>\n                    =0.019) and occipital (\n                    <jats:italic>P<\/jats:italic>\n                    =0.009) white matter (WM) than those in the controls. CBF decreased significantly with increased severity of the disease. The patients had lower mean rCMR\n                    <jats:sub>gluc<\/jats:sub>\n                    values than the controls, although differences were not statistically significant. Sum scores of semiquantitative MRI rating scale (Scheltens) correlated significantly with WM CBF but not with rCMR\n                    <jats:sub>gluc<\/jats:sub>\n                    .\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    In CADASIL, there is an early and significant decrease in the CBF of WM associated with simultaneous MRI changes. These are obviously caused by the arteriopathy in long penetrating arteries and indicate early tissue damage, also expressed as impaired rCMR\n                    <jats:sub>gluc<\/jats:sub>\n                    in the WM.\n                  <\/jats:p>","DOI":"10.1161\/01.str.0000124124.69842.2d","type":"journal-article","created":{"date-parts":[[2004,3,15]],"date-time":"2004-03-15T20:43:28Z","timestamp":1079383408000},"page":"1063-1067","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["Positron Emission Tomography Examination of Cerebral Blood Flow and Glucose Metabolism in Young CADASIL Patients"],"prefix":"10.1161","volume":"35","author":[{"given":"Susanna","family":"Tuominen","sequence":"first","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Miao","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Kurki","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Tuisku","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Po\u0308yho\u0308nen","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kalimo","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Viitanen","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu T.","family":"Sipila\u0308","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rgen","family":"Bergman","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha O.","family":"Rinne","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.Tuominen), Turku PET Centre (S.Tuominen, H.T.S., J.B., J.O.R.), Department of Pathology (Q.M., H.K.), and Department of Radiology (T.K.), Turku University Hospital and University of Turku, Turku, Finland; Department of Neurology (S.Tuisku), Keski-Pohjanmaa Central Hospital, Kokkola, Finland; Department of Medical Genetics (M.P.), Family Federation of Finland, Helsinki, Finland; Department of Pathology (H.K.), University of Helsinki and Helsinki University Hospital,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/383707a0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2002.tb00451.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91557-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440506"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.452"},{"key":"e_1_3_2_6_2","first-page":"91","volume":"20","year":"1999","unstructured":"Yousry TA, Seelos K, Mayer M, Bruning R, Uttner I, Dichgans M, Mammi S, Straube A, Mai N, Filippi M. Characteristic MR lesion pattern and correlation of T1 and T2 lesion volume with neurologic and neuropsychological findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Am J Neuroradiol. 1999; 20: 91\u2013100.","journal-title":"Am J Neuroradiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.8.1767"},{"key":"e_1_3_2_8_2","first-page":"1729","volume":"26","year":"1995","unstructured":"Chabriat H, Bousser MG, Pappata S. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: a positron emission tomography study in two affected family members. Stroke. 1995; 26: 1729\u20131730.","journal-title":"Stroke"},{"key":"e_1_3_2_9_2","first-page":"862","volume":"44","year":"2003","unstructured":"Tatsch K, Koch W, Linke R, Poepperl G, Peters N, Holtmannspoetter M, Dichgans M. Cortical hypometabolism and crossed cerebellar diaschisis suggest subcortically induced disconnection in CADASIL: an 18F-FDG PET study. J Nucl Med. 2003; 44: 862\u2013869.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.8.1904"},{"key":"e_1_3_2_11_2","first-page":"1268","volume":"22","year":"2001","unstructured":"Bruening R, Dichgans M, Berchtenbreiter C, Yousry T, Seelos KC, Wu RH, Mayer M, Brix G, Reiser M. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy: decrease in regional cerebral blood volume in hyperintense subcortical lesions inversely correlates with disability and cognitive performance. Am J Neuroradiol. 2001; 22: 1268\u20131274.","journal-title":"Am J Neuroradiol"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.11.2027"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.25804401381"},{"key":"e_1_3_2_15_2","first-page":"790","volume":"24","year":"1983","unstructured":"Raichle ME, Martin WR, Herscovitch P, Mintun MA, Markham J. Brain blood flow measured with intravenous H215O. II. Implementation and validation. J Nucl Med. 1983; 24: 790\u2013798.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_16_2","first-page":"235","volume":"27","year":"1986","unstructured":"Hamacher K, Coenen HH, St\u00f6clin G. Efficient stereospecific synthesis of non-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986; 27: 235\u2013238.","journal-title":"J Nucl Med"},{"key":"e_1_3_2_17_2","first-page":"1065","volume":"34","year":"1986","unstructured":"Solin O, Bergman J, Haaparanta M, Reissell A. Production of 18F from water targets. Specific radioactivity and anionic contaminants. Int Radiat Isot. 1986; 34: 1065\u20131071.","journal-title":"Int Radiat Isot"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-198901000-00004"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1985.87"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.3.735"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000062341.61367.D3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00396-8"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000070411.13217.7E"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.101138098"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000124124.69842.2d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:43:19Z","timestamp":1715535799000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000124124.69842.2d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1161\/01.STR.0000124124.69842.2d"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000124124.69842.2d","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"2003-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-01-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}