{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:29:20Z","timestamp":1780493360689,"version":"3.54.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            We present the results of endovascular photoacoustic recanalization (EPAR) treatment for acute ischemic stroke from the Safety and Performance Study at 6 centers in Europe and North America. The objectives of mechanical thrombolysis are rapid vessel recanalization and minimal use of chemical thrombolysis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            This study was a prospective, nonrandomized study. The National Institutes of Health Stroke Scale (NIHSS) score and the modified Rankin Scale (mRS) score were recorded before treatment. The presence of recanalization was assessed by angiography. To measure outcome, follow-up examinations were performed at 24 hours, 7 days, and 30 days after stroke onset.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Thirty-four patients (median NIHSS 19) were enrolled. Ten patients had internal carotid artery occlusion, 12 patients had middle cerebral artery occlusion, 11 patients had vertebrobasilar occlusion, and 1 patient had posterior cerebral artery occlusion. The overall recanalization rate was 41.1% (14\/34). Complete EPAR treatment was possible in 18 patients (median NIHSS 18), with vessel recanalization in 11 patients (61.1%) after EPAR. The average lasing time was 9.65 minutes. Incomplete EPAR treatment (16\/34, median NIHSS 19) was defined as intention to treat with EPAR and that the EPAR microcatheter entered the patient. Additional treatment with intraarterial application of rTPA occurred in 13 patients. An adverse event associated with use of the device occurred in 1 patient. Symptomatic hemorrhages occurred in 2 patients (5.9%). The mortality rate was 38.2%.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            This study demonstrates the safety and technical feasibility of EPAR. This new technique may provide another treatment option in the therapeutic armamentarium for patients with acute ischemic stroke.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000124126.17508.d3","type":"journal-article","created":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T01:43:28Z","timestamp":1079401408000},"page":"1112-1116","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":110,"title":["Mechanical Thrombolysis in Acute Ischemic Stroke With Endovascular Photoacoustic Recanalization"],"prefix":"10.1161","volume":"35","author":[{"given":"Ansgar","family":"Berlis","sequence":"first","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmi","family":"Lutsep","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Barnwell","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Norbash","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Wechsler","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Jungreis","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Woolfenden","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Redekop","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Hartmann","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schumacher","sequence":"additional","affiliation":[{"name":"From Department of Neuroradiology (A.B., M.S.), University of Freiburg, Germany; Department of Neurology (H.L.) and Dotter Interventional Institute (S.B.), Oregon Health and Science University, Portland, Ore; Department of Neurosurgery (A.N.), Brigham and Women\u2019s Hospital, Boston, Mass; Departments of Neurology (L.W.), Radiology (C.A.J.), and Neurosurgery (C.A.J.), University of Pittsburgh Medical Center, Pittsburgh, Pa; Departments of Neurology (A.W.) and Neurosurgery (G.R.), Vancouver General..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000020713.89227.b7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.1.4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.10.3176080"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00593977"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.3.610"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000030109.12281.23"},{"key":"e_1_3_2_8_2","first-page":"879","volume":"93","year":"1999","unstructured":"Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, Pessin M, Ahuja A, Callahan F, Clark WM, Siver F, Rivera F. Intraarterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA. 1999; 93: 879\u2013888.","journal-title":"JAMA"},{"key":"e_1_3_2_9_2","unstructured":"Farkas J Hinrichs C Cariaga T Gor D Monks R Hunt CD Hidalgo A. Intraarterial thrombolysis using r-TPA: Initial angiographic outcomes. [Abstract] ASNR Proceedings 2002; 93:80\u201381."},{"key":"e_1_3_2_10_2","first-page":"1977","volume":"16","year":"1995","unstructured":"Jansen O, von Kummer R, Forsting M, Hacke W, Sartor K. Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation. AJNR Am J Neuroradiol. 1995; 16: 1977\u20131986.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200211000-00040"},{"key":"e_1_3_2_12_2","first-page":"319-b.","volume":"32","year":"2001","unstructured":"Lutsep HL, Campbell M, Clark WM, Janson O, Lefkowitz MA, Marks M, Norbash A, Putman C, Schumacher M. EPAR therapy system for treatment of acute stroke. Stroke. 2001; 32: 319-b. Abstract.","journal-title":"Stroke"},{"key":"e_1_3_2_13_2","first-page":"1282","volume":"48","year":"2001","unstructured":"Ringer AJ, Qureshi AI, Fessler RD, Guterman LR, Hopkins LN. Angioplasty of intracranial occlusion resistant to thrombolysis in acute ischemic stroke. Neurosurgery. 2001; 48: 1282\u20131290.","journal-title":"Neurosurgery"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1051-0443(07)61978-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000024524.71680.c6"},{"key":"e_1_3_2_16_2","first-page":"534","volume":"24","year":"2003","unstructured":"Mahon BR, Nesbit GM, Barnwell SL, Clark W, Marotta TR, Weill A, Teal PA, Qureshi AI. North Am clinical experience with the EKOS MicroLysUS infusion catheter for the treatment of embolic stroke. AJNR Am J Neuroradiol. 2003; 24: 534\u2013538.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_17_2","first-page":"846","volume":"20","year":"1989","unstructured":"Brott T, Adams HP Jr, Olinger CP, Marler JR, Barsan WG, Biller J, Spilker J, Holleran R, Eberle R, Hertzberg V, Roorick M, Moomaw CJ, Walker M. Measurements of acute cerebral infarction: a clinical examination scale. Stroke. 1989; 20: 846\u2013870.","journal-title":"Stroke"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121437"},{"key":"e_1_3_2_19_2","first-page":"783","volume":"23","year":"2002","unstructured":"Lutsep HL, Clark WM, Nesbit GM et al. Intraarterial suction thrombectomy in acute stroke. AJNR Am J Neuroradiol. 2002; 23: 783\u2013786.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_20_2","first-page":"630","volume":"24","year":"2003","unstructured":"Fourie P, Duncan IC. Microsnare-Assisted Mechanical Removal of Intraprocedural Distal Middle Arterial Thromboembolism. AJNR Am J Neuroradiol. 2003; 24: 630\u2013632.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.5.3363593"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199502000-00002"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.6.667"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.5.875"},{"key":"e_1_3_2_25_2","first-page":"1557","volume":"19","year":"1998","unstructured":"Cross DT III, Moran CJ, Akins PT, Angtuaco EE, Derdeyn CP, Diringer MN. Collateral circulation and outcome after basilar artery thrombolysis. AJNR Am J Neuroradiol. 1998; 19: 1557\u20131563.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.33.3.717"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.6.739"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000124126.17508.d3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:44:01Z","timestamp":1715550241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000124126.17508.d3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1161\/01.STR.0000124126.17508.d3"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000124126.17508.d3","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"2003-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}