{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:22:03Z","timestamp":1791033723034,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    This work was undertaken to determine to what degree long-term neurofunctional outcome of neonatal hypoxic\u2013ischemic (HI) brain injury in mice correlates with anatomical extent of cerebral damage assessed by magnetic resonance imaging (MRI) and histopathology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    On postnatal day 7, mice were subjected to HI. At 7 to 9 weeks after HI neurofunctional outcome was assessed by water-maze, rota-rod, and open-field test performance, followed by cerebral MRI and histopathology evaluation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    At 10 weeks after HI, MRI revealed ipsilateral brain atrophy alone or with porencephalic cyst formation and contralateral ventriculomegaly. Adult HI-affected mice, especially those that developed a porencephalic cyst, demonstrated significant neurofunctional deficit compared with age-matched nai\u0308ve mice. HI-affected mice with ipsilateral cerebral atrophy but without porencephaly demonstrated no or an intermediate level of neurofunctional deficit. Neurobehavioral assessment of mice subjected to HI insult revealed a strong correlation between degree of brain injury and functional neurohandicap.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    This is the first study to demonstrate that long-term neurofunctional outcome in mice after a neonatal HI correlates tightly with anatomical pattern\/extent of cerebral damage, defined by MRI and histopathology.\n                  <\/jats:p>","DOI":"10.1161\/01.str.0000137768.25203.df","type":"journal-article","created":{"date-parts":[[2004,7,23]],"date-time":"2004-07-23T21:47:57Z","timestamp":1090619277000},"page":"2183-2188","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":83,"title":["Late Measures of Brain Injury After Neonatal Hypoxia\u2013Ischemia in Mice"],"prefix":"10.1161","volume":"35","author":[{"given":"Vadim S.","family":"Ten","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed X.","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Tang","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bradley-Moore","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim V.","family":"Fedarau","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veniamin I.","family":"Ratner","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; and the Department of Medicine (M.V.F., D.J.P.), University of Michigan, Ann Arbor, Mich."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond I.","family":"Stark","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics (V.S.T., V.I.R., R.I.S.), Radiology (E.X.W., H.T.), Developmental Psychobiology (M.B.-M.), and Psychiatry (J.A.G.), Columbia University, New York, NY; 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