{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:42:53Z","timestamp":1775749373603,"version":"3.50.1"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The local renin-angiotensin system (RAS) and cyclooxygenase-2 contribute to the activation of nuclear factor \u03baB (NF\u03baB) and C-reactive protein (CRP). We hypothesized that the combination of RAS blockers (RASb) and ASA reduces NF\u03baB and CRP within atherosclerotic plaques.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Patients undergoing carotid endarterectomy were divided into groups according to treatment (RASb\u2013acetylsalicylic acid [ASA], ASA, RASb, and control). The expression of NF\u03baB, CRP, and CD40L was analyzed through Western blots in the obtained plaques.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Plaques from patients treated with the combination of RASb and ASA showed lower expression of NF\u03baB (25.4\u00b19.8 densitometric units [DU]) than those of the control group (57.6\u00b113.2 DU,\n            <jats:italic>P<\/jats:italic>\n            =0.03) as well as lower expression of CRP (20.9\u00b19.6 DU) than those of the other treatment groups (ASA 86.1\u00b113 DU, RASb 88.4\u00b131 DU, controls 67.8\u00b118.6,\n            <jats:italic>P<\/jats:italic>\n            =0.004). A negative expression of NF\u03baB was associated with a reduced incidence of symptoms compared with a positive expression (5\/33 [15.1%] versus 14\/35 [40%],\n            <jats:italic>P<\/jats:italic>\n            =0.031).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The combined treatment with RASb and ASA decreases the expression of inflammatory markers in atherosclerosis in humans. This study supports the role of the local RAS and cyclooxygenase-2 in the progression of atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000150643.08420.78","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T01:39:03Z","timestamp":1102037943000},"page":"14-20","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Concurrent Treatment With Renin-Angiotensin System Blockers and Acetylsalicylic Acid Reduces Nuclear Factor \u03baB Activation and C-Reactive Protein Expression in Human Carotid Artery Plaques"],"prefix":"10.1161","volume":"36","author":[{"given":"Katherine J.E.","family":"Sattler","sequence":"first","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie E.","family":"Woodrum","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Offer","family":"Galili","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Olson","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saquib","family":"Samee","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric B.","family":"Meyer","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Yang","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., J.E.W., O.G., M.O., S.S., A.L., X.-Y.Z., L.O.L.), Department of Internal Medicine; and the Department of Neurosurgery (F.B.M.), Mayo Clinic Rochester, Minn."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Lerman","sequence":"additional","affiliation":[{"name":"From the Divisions of Cardiovascular Diseases, Nephrology, and Hypertension (K.J.E.S., 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