{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:13:25Z","timestamp":1790417605382,"version":"4.1.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            We evaluated whether basal\/acetazolamide stress brain perfusion SPECT performed after revascularization surgery can predict the further clinical outcome of patients with pediatric moyamoya disease.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            A total of 77 (31 males, 46 females, age 6.6\u00b13.2 years) patients with postoperative pediatric moyamoya disease who underwent basal\/acetazolamide stress brain perfusion SPECT 6 to 12 months after revascularization surgery and who were followed-up &gt;12 months after SPECT were included. Mean follow-up period after SPECT was 36\u00b119 months. Sixty-two patients underwent bilateral ribbon encephaloduroarteriosynangiosis (EDAS), 14 bilateral EDAS, and 1 unilateral EDAS. Ordinal logistic regression analysis using 5 independent variables (infarction on preoperative MRI, age at the first operation, highest Suzuki stage on cerebral angiography, and regional cerebrovascular reserve on postoperative SPECT) against postoperative clinical outcomes was performed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Fifty-one patients had preserved reserve on postoperative SPECT and their clinical outcomes were excellent (30), good (15), fair (4), and poor (2); 26 patients had decreased reserve (excellent, 1; good, 7; fair, 14; poor, 4). On ordinal logistic regression analysis, age at the first operation (\n            <jats:italic>P<\/jats:italic>\n            =0.033) and reserve on postoperative SPECT (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) were statistically significant.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Basal\/acetazolamide stress brain perfusion SPECT performed at 6 to 12 months after the indirect bypass operation could predict the further clinical outcome of pediatric patients with moyamoya disease. Patients with decreased cerebrovascular reserve will have remaining neurological deficit and ischemic attacks on follow-up.\n          <\/jats:p>","DOI":"10.1161\/01.str.0000170709.95185.b1","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T00:45:08Z","timestamp":1118364308000},"page":"1485-1489","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":103,"title":["Prediction of the Clinical Outcome of Pediatric Moyamoya Disease With Postoperative Basal\/Acetazolamide Stress Brain Perfusion SPECT After Revascularization Surgery"],"prefix":"10.1161","volume":"36","author":[{"given":"Young","family":"So","sequence":"first","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjoo","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Departments of Nuclear Medicine (Y.S., H.-Y.L., J.S.L., E.K., D.S.L.) and Neurosurgery (S.-K.K., K.-C.W., B.-K.C.), Seoul National University College of Medicine, Korea; and the Department of Nuclear Medicine, Konkuk University, College of Medicine (Y.S.), Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.18.5.485"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.14.1.6823678"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.2.282"},{"key":"e_1_3_2_5_2","first-page":"314","volume":"32","year":"1998","unstructured":"Lee DS, Hyun IY, Wang KC, Cho BK, Chung J-K, Lee MC. 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Neurosurg Clin North Am. 2001; 36: 575\u2013584.","journal-title":"Neurosurg Clin North Am"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.15.5.6474539"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007010050213"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199304000-00006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.8.1342"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(89)90065-7"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000170709.95185.b1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:42:49Z","timestamp":1715550169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000170709.95185.b1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1161\/01.STR.0000170709.95185.b1"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000170709.95185.b1","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"2005-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}