{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:30:54Z","timestamp":1791203454593,"version":"4.2.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2006,2]]},"abstract":"\n \n Background and Purpose\u2014<\/jats:italic>\n <\/jats:bold>\n Apolipoprotein E genotype<\/jats:italic>\n (\n APOE<\/jats:italic>\n ) is associated with cholesterol metabolism, ischemic heart disease, and cerebral amyloid angiopathy, and so may affect risk of both ischemic and hemorrhagic stroke.\n <\/jats:p>\n \n \n Methods\u2014<\/jats:italic>\n <\/jats:bold>\n We comprehensively sought and identified studies of the association of apoE with ischemic stroke (IS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). We did meta-analyses to assess the evidence for an association between\n APOE<\/jats:italic>\n and the various pathological types and subtypes of stroke, and assessed the effects of several methodological criteria.\n <\/jats:p>\n \n \n Results\u2014<\/jats:italic>\n <\/jats:bold>\n We analyzed data from 31 eligible studies (26 IS, 8 ICH, and 3 SAH) in 5961 cases and 17 965 controls. \u03b54 allele\u2013containing (\u03b54+) genotypes were significantly associated with IS (odds ratio [OR], 1.11; 95% CI, 1.01 to 1.22) and SAH (OR, 1.42; 95% CI, 1.01 to 1.99) and nonsignificantly with ICH (OR, 1.16; 95% CI, 0.93 to 1.44), whereas \u03b52+ genotypes were associated with ICH (OR, 1.32; 95% CI, 1.01 to 1.74). Associations appeared stronger with \u03b54+ genotypes for large artery compared with other IS subtypes and for Asian compared with white populations, and with \u03b52+ genotypes for lobar compared with deep hemorrhages. However, we found no association between \u03b54+ genotypes and IS when we analyzed only larger studies (>200 cases; OR, 0.99; 95% CI, 0.88 to 1.11) or studies without control selection bias (OR, 0.99; 95% CI, 0.85 to 1.17).\n <\/jats:p>\n \n \n Conclusions\u2014<\/jats:italic>\n <\/jats:bold>\n Publication and selection biases make existing studies of\n APOE<\/jats:italic>\n and stroke unreliable. Further, very large, methodologically rigorous studies are needed.\n <\/jats:p>","DOI":"10.1161\/01.str.0000199065.12908.62","type":"journal-article","created":{"date-parts":[[2005,12,30]],"date-time":"2005-12-30T01:48:18Z","timestamp":1135907298000},"page":"364-370","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":137,"title":["Does\n Apolipoprotein E Genotype<\/i>\n Influence the Risk of Ischemic Stroke, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage?"],"prefix":"10.1161","volume":"37","author":[{"given":"Cathie","family":"Sudlow","sequence":"first","affiliation":[{"name":"From the Division of Clinical Neurosciences (C.S., N.A.M.G.), Medical Genetics Section (C.S.), and Medical School (J.K., C.C.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahara Anani\u0301","family":"Marti\u0301nez Gonza\u0301lez","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Neurosciences (C.S., N.A.M.G.), Medical Genetics Section (C.S.), and Medical School (J.K., C.C.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Neurosciences (C.S., N.A.M.G.), Medical Genetics Section (C.S.), and Medical School (J.K., C.C.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Clark","sequence":"additional","affiliation":[{"name":"From the Division of Clinical Neurosciences (C.S., N.A.M.G.), Medical Genetics Section (C.S.), and Medical School (J.K., C.C.), University of Edinburgh, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000107187.84390.aa"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014774.88027.22"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.2.249"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014773.57733.3e"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000121646.23955.0f"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000158920.67013.53"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.9.1784"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.11.1652"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.10.1483"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)82009-7"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12386-0"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000177498.21594.9e"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.6.487"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-2-200407200-00013"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00708-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.6.1308"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.961"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06366.x"},{"key":"e_1_3_2_19_2","unstructured":"http:\/\/www.cc-ims.net\/RevMan\/current.htm. Accessed October 1 2005."},{"key":"e_1_3_2_20_2","first-page":"719","volume":"22","year":"1959","unstructured":"Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959; 22: 719\u2013748.","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7124.61"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/375613"},{"key":"e_1_3_2_23_2","unstructured":"www.ukbiobank.ac.uk. Accessed October 1 2005."}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/01.STR.0000199065.12908.62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:35:53Z","timestamp":1715549753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.0000199065.12908.62"}},"subtitle":["Systematic Review and Meta-Analyses of 31 Studies Among 5961 Cases and 17 965 Controls"],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1161\/01.STR.0000199065.12908.62"],"URL":"https:\/\/doi.org\/10.1161\/01.str.0000199065.12908.62","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"2005-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}