{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:23:59Z","timestamp":1790868239319,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>Etiology, clinical manifestations and outcome were reviewed in 139 cases of \"locked-in syndrome.\" Six cases were reported from our center and the remaining 133 cases were taken from a review of the literature. The results of this review emphasized the necessity for a comprehensive program of pulmonary management in this population. Furthermore, an effective system of communication for the patient is considered essential in the management of the \"locked-in\" state. Reported mortality in the cases reviewed was 60%. Overall, the prognosis for survival and recovery was found to be better in the group of patients whose syndrome was nonvascular in origin than those with a vascular etiology. Functional recovery was generally good in those patients with a vascular etiology who survived beyond 4 months while recovery occurred earlier and more completely in the nonvascular group. Thus, a program of intensive rehabilitation should be considered early in both groups in order to assist each patient in attaining the highest level of function possible as recovery progresses.<\/jats:p>","DOI":"10.1161\/01.str.17.4.758","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T16:08:03Z","timestamp":1308326883000},"page":"758-764","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":241,"title":["Locked-in syndrome: a review of 139 cases."],"prefix":"10.1161","volume":"17","author":[{"given":"J R","family":"Patterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Grabois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.17.4.758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:51:27Z","timestamp":1715536287000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.17.4.758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1161\/01.STR.17.4.758"],"URL":"https:\/\/doi.org\/10.1161\/01.str.17.4.758","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]},"assertion":[{"value":"1986-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}