{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:30:59Z","timestamp":1769455859106,"version":"3.49.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1971,5]]},"abstract":"<jats:p>\n            The mechanisms whereby CO\n            <jats:sub>2<\/jats:sub>\n            affects cerebral vessels are not as simple as once thought,\n            <jats:sup>1, 2<\/jats:sup>\n            and are probably both directly on cerebral vascular walls\n            <jats:sup>3, 4<\/jats:sup>\n            and indirectly by action on brain stem neurones.\n            <jats:sup>5<\/jats:sup>\n            Furthermore, cerebral vascular reactivity to CO\n            <jats:sub>2<\/jats:sub>\n            has been reported to be altered by a number of physiological and pathological circumstances. The capacity to dilate to increased Pa\n            <jats:sub>\n              CO\n              <jats:sub>CO2<\/jats:sub>\n            <\/jats:sub>\n            is decreased in cerebral vascular lesions,\n            <jats:sup>6-8<\/jats:sup>\n            and is affected by changes in cerebral perfusion pressure.\n            <jats:sup>9<\/jats:sup>\n            Cervical sympathectomy is said to increase CBF response to Pa\n            <jats:sub>\n              CO\n              <jats:sub>CO2<\/jats:sub>\n            <\/jats:sub>\n            changes, whereas sympathetic nerve stimulation abolishes reactivity to CO\n            <jats:sub>2<\/jats:sub>\n            .\n            <jats:sup>10<\/jats:sup>\n            Deep anesthesia, hypothermia, or trauma to brain reduces reactivity to cerebral vessels to CO\n            <jats:sub>2<\/jats:sub>\n            , the one common denominator for these states being reduced cerebral metabolism. This report demonstrates that the capacity of cerebral vessels to dilate or constrict in response to changes in Pa\n            <jats:sub>\n              CO\n              <jats:sub>CO2<\/jats:sub>\n            <\/jats:sub>\n            is influenced by cerebral oxygen consumption.\n          <\/jats:p>","DOI":"10.1161\/01.str.2.3.251","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"251-257","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["The Relation Between Cerebral Oxygen Consumption and Cerebral Vascular Reactivity to Carbon Dioxide"],"prefix":"10.1161","volume":"2","author":[{"given":"MASATOSHI","family":"FUJISHIMA","sequence":"first","affiliation":[{"name":"Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PERITZ","family":"SCHEINBERG","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAUL","family":"BUSTO","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OSCAR M.","family":"REINMUTH","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Miami School of Medicine, Miami, Florida, 33152"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.2.3.251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:31:00Z","timestamp":1715549460000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.2.3.251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,5]]}},"alternative-id":["10.1161\/01.STR.2.3.251"],"URL":"https:\/\/doi.org\/10.1161\/01.str.2.3.251","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1971,5]]},"assertion":[{"value":"1971-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}