{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:05:55Z","timestamp":1772463955747,"version":"3.50.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>We examined the effects of MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger and an inhibitor of ischemia-induced brain edema, on monoamine metabolism in the brains of both normal and ischemic rats. In normal rats, 3 mg\/kg i.v. MCI-186, a dose that prevents ischemic brain edema, had no significant effect on brain concentrations of dopamine, norepinephrine, 5-hydroxytryptamine, or their metabolites. After the injection of 5 microliters of 3% polyvinyl acetate into the left internal carotid artery, concentrations of 3,4-dihydroxyphenylacetic acid and homovanillic acid markedly increased, but that of norepinephrine decreased, in the left telencephalon of embolized rats compared with control rats injected with vehicle; the concentration of 5-hydroxyindoleacetic acid also increased slightly. These effects were maximal 2 hours after embolization. The turnover rate of dopamine between 6 and 8 hours after embolization was significantly higher but that of norepinephrine was slightly lower than that in vehicle-treated rats. When rats were treated with 3 mg\/kg i.v. MCI-186 immediately after the injection of polyvinyl acetate, the embolization-induced changes in monoamine metabolism were less marked. Our results suggest that MCI-186 attenuates ischemia-induced changes in brain monoamine metabolism, probably due to its free radical scavenging action, although it has no marked effect in normal rats.<\/jats:p>","DOI":"10.1161\/01.str.20.11.1557","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:10:52Z","timestamp":1308341452000},"page":"1557-1564","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Effect of MCI-186 on ischemia-induced changes in monoamine metabolism in rat brain."],"prefix":"10.1161","volume":"20","author":[{"given":"R","family":"Oishi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Nishibori","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Okayama University Medical School, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.20.11.1557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:33:41Z","timestamp":1715549621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.20.11.1557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1161\/01.STR.20.11.1557"],"URL":"https:\/\/doi.org\/10.1161\/01.str.20.11.1557","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]},"assertion":[{"value":"1989-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}