{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T20:12:13Z","timestamp":1726085533908},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:p>We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. time in a 1.89 T magnet. Mean +\/- SD blood:brain partition coefficients for Freon-22 were estimated at 0.93 +\/- 0.08 for gray matter and 0.77 +\/- 0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean +\/- SD resting cerebral blood flow were 50 +\/- 19 ml\/100 g-min for gray matter and 5.0 +\/- 2.0 ml\/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.<\/jats:p>","DOI":"10.1161\/01.str.20.2.259","type":"journal-article","created":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T20:08:03Z","timestamp":1308341283000},"page":"259-267","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Cerebral blood flow measured by NMR indicator dilution in cats."],"prefix":"10.1161","volume":"20","author":[{"given":"J R","family":"Ewing","sequence":"first","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Branch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Helpern","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M B","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Welch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/pdf\/10.1161\/01.STR.20.2.259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:47:16Z","timestamp":1715550436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.20.2.259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1161\/01.STR.20.2.259"],"URL":"https:\/\/doi.org\/10.1161\/01.str.20.2.259","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,2]]},"assertion":[{"value":"1989-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}